Autophagy and Its Role in Spinal Cord Injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00500147" target="_blank" >RIV/68378041:_____/18:00500147 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Autophagy and Its Role in Spinal Cord Injury

Popis výsledku v původním jazyce

Autophagy is a widely studied process involved in maintaining cellular homeostasis, clearance and degradation of faulty or excess proteins and organelles and ultimately in refreshing the intracellular space. It is highly regulated and constitutively present in cells across species. Defects in autophagy have been associated with a number of pathologies, such as cancer or neurodegenerative diseases often linked with accumulation of misfolded or aggregated proteins. It has been shown to be active after trauma to the spinal cord and may be the key target for spinal cord injury (SCI) therapy. In this review, the process of autophagy is described and crucial phases in the development of functional autolysosome are highlighted, both under conditions of nutritional deficits or after SCI along with therapies aiming to enhance it.n

Název v anglickém jazyce

Autophagy and Its Role in Spinal Cord Injury

Popis výsledku anglicky

Autophagy is a widely studied process involved in maintaining cellular homeostasis, clearance and degradation of faulty or excess proteins and organelles and ultimately in refreshing the intracellular space. It is highly regulated and constitutively present in cells across species. Defects in autophagy have been associated with a number of pathologies, such as cancer or neurodegenerative diseases often linked with accumulation of misfolded or aggregated proteins. It has been shown to be active after trauma to the spinal cord and may be the key target for spinal cord injury (SCI) therapy. In this review, the process of autophagy is described and crucial phases in the development of functional autolysosome are highlighted, both under conditions of nutritional deficits or after SCI along with therapies aiming to enhance it.n

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LO1309" target="_blank" >LO1309: Buněčná terapie a tkáňové náhrady</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanostructures in Biomedicine: Their Regenerative and toxic properties

ISBN

978-80-906655-7-6

Počet stran výsledku

6

Strana od-do

188-193

Počet stran knihy

198

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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