The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00508394" target="_blank" >RIV/68378041:_____/19:00508394 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1582770" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1582770</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10715762.2019.1582770" target="_blank" >10.1080/10715762.2019.1582770</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved

Popis výsledku v původním jazyce

Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Molecular hydrogen (H-2) is very suitable for this purpose due to its unique properties. H-2 is the only antioxidant that crosses the blood-brain and blood-ocular barriers. It quickly penetrates through tissue due to its small molecular size and effectively removes ROS, mainly hydroxyl radicals and peroxynitrite. Apart from its antioxidant effects, H-2 also displays anti-inflammatory, antiapoptotic, cytoprotective and mitohormetic properties. A significant advantage of H-2 is its nontoxicity, even when applied at high concentrations. In this review, we present the results of studies utilising H-2 in the treatment of ocular diseases involving oxidative stress. These results, obtained in experimental animals as well as in human clinical studies, show that the suppression of oxidative stress by H-2 treatment leads to the prevention or improvement of ocular diseases. In severe degenerative diseases, H-2 slows disease progression.

Název v anglickém jazyce

The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved

Popis výsledku anglicky

Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Molecular hydrogen (H-2) is very suitable for this purpose due to its unique properties. H-2 is the only antioxidant that crosses the blood-brain and blood-ocular barriers. It quickly penetrates through tissue due to its small molecular size and effectively removes ROS, mainly hydroxyl radicals and peroxynitrite. Apart from its antioxidant effects, H-2 also displays anti-inflammatory, antiapoptotic, cytoprotective and mitohormetic properties. A significant advantage of H-2 is its nontoxicity, even when applied at high concentrations. In this review, we present the results of studies utilising H-2 in the treatment of ocular diseases involving oxidative stress. These results, obtained in experimental animals as well as in human clinical studies, show that the suppression of oxidative stress by H-2 treatment leads to the prevention or improvement of ocular diseases. In severe degenerative diseases, H-2 slows disease progression.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

<a href="/cs/project/LO1309" target="_blank" >LO1309: Buněčná terapie a tkáňové náhrady</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Free Radical Research

ISSN

1071-5762

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

237-247

Kód UT WoS článku

000463483900001

EID výsledku v databázi Scopus

2-s2.0-85065655228