Fecal microRNAs as non-invasive biomarkers for the detection of colorectal cancer: a systematic review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00517910" target="_blank" >RIV/68378041:_____/19:00517910 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.minervamedica.it/en/journals/minerva-biotecnologica/article.php?cod=R04Y2019N01A0030" target="_blank" >https://www.minervamedica.it/en/journals/minerva-biotecnologica/article.php?cod=R04Y2019N01A0030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S1120-4826.18.02495-3" target="_blank" >10.23736/S1120-4826.18.02495-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fecal microRNAs as non-invasive biomarkers for the detection of colorectal cancer: a systematic review

Popis výsledku v původním jazyce

INTRODUCTION: Colorectal cancer (CRC) is currently still one of the most frequent cancers worldwide. Even if the available screening tests have helped to reduce incidence and mortality for this cancer, new potential biomarkers to use in concomitance could improve effectiveness of CRC detection. microRNAs (miRNAs) are the most famous class of small non-coding RNAs which regulate several biological processes. They are stable and easily detectable in different biospecimens and their expression has been reported dysregulated in many diseases, including CRC. Stool miRNAs, in particular, seem really interesting as potential noninvasive diagnostic CRC biomarkers. nnEVIDENCE ACQUISITION: We have systematically reviewed all the studies investigating miRNAs dysregulation in stool in relation to CRC. Nineteen different works were included in the present review. nnEVIDENCE SYNTHESIS: The retrieved studies mostly investigated fecal miRNA expression levels (often together with tumor/healthy tissues, and in a couple of studies, also in plasma/serum) by RT-qPCR or microarray. Globally, 51 miRNAs were reported as dysregulated in CRC patients compared to controls: 32 up-regulated and 19 down-regulated. Among them, miR-106a, miR-17, miR-18a, miR-20a, miR-21, miR-92a, miR-96, miR-223 and miR-143 expression levels have been described as altered by more than two studies. nnCONCLUSIONS: The relatively few available studies so far demonstrate the feasibility and a good potentiality of non-invasive stool miRNA-based test for the detection of CRC, reflecting same altered expression as in primary tissue. For this reason, the whole miRNome needs to be exhaustively explored in human stool samples with further investigations on larger study populations of CRC cases and controls.

Název v anglickém jazyce

Fecal microRNAs as non-invasive biomarkers for the detection of colorectal cancer: a systematic review

Popis výsledku anglicky

INTRODUCTION: Colorectal cancer (CRC) is currently still one of the most frequent cancers worldwide. Even if the available screening tests have helped to reduce incidence and mortality for this cancer, new potential biomarkers to use in concomitance could improve effectiveness of CRC detection. microRNAs (miRNAs) are the most famous class of small non-coding RNAs which regulate several biological processes. They are stable and easily detectable in different biospecimens and their expression has been reported dysregulated in many diseases, including CRC. Stool miRNAs, in particular, seem really interesting as potential noninvasive diagnostic CRC biomarkers. nnEVIDENCE ACQUISITION: We have systematically reviewed all the studies investigating miRNAs dysregulation in stool in relation to CRC. Nineteen different works were included in the present review. nnEVIDENCE SYNTHESIS: The retrieved studies mostly investigated fecal miRNA expression levels (often together with tumor/healthy tissues, and in a couple of studies, also in plasma/serum) by RT-qPCR or microarray. Globally, 51 miRNAs were reported as dysregulated in CRC patients compared to controls: 32 up-regulated and 19 down-regulated. Among them, miR-106a, miR-17, miR-18a, miR-20a, miR-21, miR-92a, miR-96, miR-223 and miR-143 expression levels have been described as altered by more than two studies. nnCONCLUSIONS: The relatively few available studies so far demonstrate the feasibility and a good potentiality of non-invasive stool miRNA-based test for the detection of CRC, reflecting same altered expression as in primary tissue. For this reason, the whole miRNome needs to be exhaustively explored in human stool samples with further investigations on larger study populations of CRC cases and controls.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

<a href="/cs/project/GA17-16857S" target="_blank" >GA17-16857S: Identifikace a porovnání miRNA signatur v plazmě a ve stolici pacientů s nádory tlustého střeva a konečníku metodou skevenování nové generace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Minerva Biotecnologica

ISSN

1120-4826

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

13

Strana od-do

30-42

Kód UT WoS článku

000465069700005

EID výsledku v databázi Scopus

2-s2.0-85060269576