DNA repair capacity and response to treatment of colon cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518156" target="_blank" >RIV/68378041:_____/19:00518156 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/19:10397883 RIV/00216208:11110/19:10397883 RIV/00216208:11120/19:43919140 RIV/00064190:_____/19:N0000021

Výsledek na webu

<a href="https://www.futuremedicine.com/doi/10.2217/pgs-2019-0070" target="_blank" >https://www.futuremedicine.com/doi/10.2217/pgs-2019-0070</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/pgs-2019-0070" target="_blank" >10.2217/pgs-2019-0070</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DNA repair capacity and response to treatment of colon cancer

Popis výsledku v původním jazyce

DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed.

Název v anglickém jazyce

DNA repair capacity and response to treatment of colon cancer

Popis výsledku anglicky

DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmacogenomics

ISSN

1462-2416

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1225-1233

Kód UT WoS článku

000507615600005

EID výsledku v databázi Scopus

2-s2.0-85075885615