EXPOSURE TO COPPER OXIDE NANOPARTICLES: BIOLOGICAL IMPACTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00523420" target="_blank" >RIV/68378041:_____/19:00523420 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EXPOSURE TO COPPER OXIDE NANOPARTICLES: BIOLOGICAL IMPACTS

Popis výsledku v původním jazyce

Copper (Cu) is a biogenic element that plays an important role in many biological processes. Cu is also used in various industrial products and its nanosized form has antibacterial and antiviral properties. Cu nanoparticles (NPs) are further applied in industry, chemistry and electronic devices. When compared with other metal oxide NPs, Cu NPs are less commonly used. However, the potential of copper oxide NPs (CuO NPs) to induce cytotoxicity and DNA damage in vitro was higher than that of other tested NPs. Despite this fact, studies on CuO NPs toxicity are relatively scarce and their effects on human health have never been investigated. In vitro tests in model cell lines showed the ability of CuO NPs to cause oxidative stress, but induction of apoptosis and cell cycle arrest were also observed. In animal studies, inflammatory responses in lungs were most common, but some studies revealed damage to other organs, including the brain. Considering toxicity of CuO NPs and the fact that these NPs are routinely manufactured and used in various products, more research is needed to elucidate mechanisms of their negative health effects in humans.

Název v anglickém jazyce

EXPOSURE TO COPPER OXIDE NANOPARTICLES: BIOLOGICAL IMPACTS

Popis výsledku anglicky

Copper (Cu) is a biogenic element that plays an important role in many biological processes. Cu is also used in various industrial products and its nanosized form has antibacterial and antiviral properties. Cu nanoparticles (NPs) are further applied in industry, chemistry and electronic devices. When compared with other metal oxide NPs, Cu NPs are less commonly used. However, the potential of copper oxide NPs (CuO NPs) to induce cytotoxicity and DNA damage in vitro was higher than that of other tested NPs. Despite this fact, studies on CuO NPs toxicity are relatively scarce and their effects on human health have never been investigated. In vitro tests in model cell lines showed the ability of CuO NPs to cause oxidative stress, but induction of apoptosis and cell cycle arrest were also observed. In animal studies, inflammatory responses in lungs were most common, but some studies revealed damage to other organs, including the brain. Considering toxicity of CuO NPs and the fact that these NPs are routinely manufactured and used in various products, more research is needed to elucidate mechanisms of their negative health effects in humans.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2018 - Conference Proceedings, 10th Anniversary International Conference on Nanomaterials - Research and Application

ISBN

978-808729489-5

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

537-542

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

17. 10. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000513131900093