Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539298" target="_blank" >RIV/68378041:_____/20:00539298 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/20:10405230 RIV/00216208:11140/20:10405230

Výsledek na webu

<a href="https://www.nature.com/articles/s41467-020-14389-8" target="_blank" >https://www.nature.com/articles/s41467-020-14389-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-020-14389-8" target="_blank" >10.1038/s41467-020-14389-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Popis výsledku v původním jazyce

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies, however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

Název v anglickém jazyce

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Popis výsledku anglicky

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies, however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

2041-1723

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

597

Kód UT WoS článku

000543983400003

EID výsledku v databázi Scopus

2-s2.0-85078709648