Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539309" target="_blank" >RIV/68378041:_____/20:00539309 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/20:E0108445

Výsledek na webu

<a href="https://www.nature.com/articles/s41375-019-0619-1" target="_blank" >https://www.nature.com/articles/s41375-019-0619-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41375-019-0619-1" target="_blank" >10.1038/s41375-019-0619-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

Popis výsledku v původním jazyce

Multiple myeloma (MM) is caused by a clonal proliferation of malignant plasma cells in the bone marrow preceded by monoclonal gammopathy of unknown signifikance (MGUS). MGUS can also progress to immunoglobulin light chain amyloidosis (amyloidosis AL). While genome-wide association studies (GWAS)-based germline genetics of each of these have been published, it is not well known to what extent their genetic profiles may be shared. Meta analysis combining large GWAS datasets of the three dyscrasias show strong evidence on shared germline genetics for the three plasma cell dyscrasias.nHowever, future studies are needed to decipher the functional basis of the risk SNPs. The most significant association at chromosome 7p15.3 (rs75341503) has been identified as a binding site for IRF4 and may offer a therapeutic target for the three dyscrasiasn

Název v anglickém jazyce

Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

Popis výsledku anglicky

Multiple myeloma (MM) is caused by a clonal proliferation of malignant plasma cells in the bone marrow preceded by monoclonal gammopathy of unknown signifikance (MGUS). MGUS can also progress to immunoglobulin light chain amyloidosis (amyloidosis AL). While genome-wide association studies (GWAS)-based germline genetics of each of these have been published, it is not well known to what extent their genetic profiles may be shared. Meta analysis combining large GWAS datasets of the three dyscrasias show strong evidence on shared germline genetics for the three plasma cell dyscrasias.nHowever, future studies are needed to decipher the functional basis of the risk SNPs. The most significant association at chromosome 7p15.3 (rs75341503) has been identified as a binding site for IRF4 and may offer a therapeutic target for the three dyscrasiasn

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Leukemia

ISSN

0887-6924

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

1187-1191

Kód UT WoS článku

000522798800024

EID výsledku v databázi Scopus

2-s2.0-85074865437