An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00538432" target="_blank" >RIV/68378041:_____/21:00538432 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41370-020-0253-z" target="_blank" >https://www.nature.com/articles/s41370-020-0253-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41370-020-0253-z" target="_blank" >10.1038/s41370-020-0253-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process

Popis výsledku v původním jazyce

Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the endocrine system and cause adverse effects. We aimed to classify the effects of 24 known EDCs, prevalent in certain occupations, according to four modes of action (estrogenic, antiestrogenic, androgenic, and/or antiandrogenic). A literature search, stratified into four types of literature was conducted (namely: national and international agency reports, review articles, primary studies, ToxCast(TM)). The state of the evidence of each EDC on sex hormone function was summarized and reviewed by an expert panel. For each mode of action, the experts evaluated the likelihood of endocrine disruption in five categories: No, Unlikely, Possibly, Probably, and Yes. Seven agents were categorized as Yes, or having strong evidence for their effects on sex hormone function (antiandrogenic: lead, arsenic, butylbenzyl phthalate, dibutyl phthalate, dicyclohexyl phthalate, estrogenic: nonylphenol, bisphenol A). Nine agents were categorized as Probable, or having probable evidence (antiandrogenic: bis(2-ethylhexyl)phthalate, nonylphenol, toluene, bisphenol A, diisononyl phthalate, androgenic: cadmium, estrogenic: copper, cadmium and, anti-estrogenic: lead). Two agents (arsenic, polychlorinated biphenyls) had opposing conclusions supporting both probably estrogenic and antiestrogenic effects. This synthesis will allow researchers to evaluate the health effects of selected EDCs with an added level of precision related to the mode of action.

Název v anglickém jazyce

An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process

Popis výsledku anglicky

Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the endocrine system and cause adverse effects. We aimed to classify the effects of 24 known EDCs, prevalent in certain occupations, according to four modes of action (estrogenic, antiestrogenic, androgenic, and/or antiandrogenic). A literature search, stratified into four types of literature was conducted (namely: national and international agency reports, review articles, primary studies, ToxCast(TM)). The state of the evidence of each EDC on sex hormone function was summarized and reviewed by an expert panel. For each mode of action, the experts evaluated the likelihood of endocrine disruption in five categories: No, Unlikely, Possibly, Probably, and Yes. Seven agents were categorized as Yes, or having strong evidence for their effects on sex hormone function (antiandrogenic: lead, arsenic, butylbenzyl phthalate, dibutyl phthalate, dicyclohexyl phthalate, estrogenic: nonylphenol, bisphenol A). Nine agents were categorized as Probable, or having probable evidence (antiandrogenic: bis(2-ethylhexyl)phthalate, nonylphenol, toluene, bisphenol A, diisononyl phthalate, androgenic: cadmium, estrogenic: copper, cadmium and, anti-estrogenic: lead). Two agents (arsenic, polychlorinated biphenyls) had opposing conclusions supporting both probably estrogenic and antiestrogenic effects. This synthesis will allow researchers to evaluate the health effects of selected EDCs with an added level of precision related to the mode of action.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30305 - Occupational health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Exposure Science and Environmental Epidemiology

ISSN

1559-0631

e-ISSN

1559-064X

Svazek periodika

31

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

753-768

Kód UT WoS článku

000551804500001

EID výsledku v databázi Scopus

2-s2.0-85088456694