Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00560832" target="_blank" >RIV/68378041:_____/21:00560832 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10436465 RIV/60461373:22330/21:43923678 RIV/00027022:_____/22:1139

Výsledek na webu

<a href="https://www.mdpi.com/2410-3888/6/4/70" target="_blank" >https://www.mdpi.com/2410-3888/6/4/70</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/fishes6040070" target="_blank" >10.3390/fishes6040070</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication

Popis výsledku v původním jazyce

Parvalbumin is considered a major fish allergen. Here, we report the molecular evolution of the parvalbumin genes in bony fishes based on 19 whole genomes and 70 transcriptomes. We found unexpectedly high parvalbumin diversity in teleosts, three main gene types (pvalb-alpha, pvalb-beta 1, and pvalb-beta 2, including oncomodulins) originated at the onset of vertebrates. Teleosts have further multiplied the parvalbumin gene repertoire up to nine ancestral copies-two copies of pvalb-alpha, two copies of pvalb-beta 1, and five copies of pvalb-beta 2. This gene diversity is a result of teleost-specific whole-genome duplication. Two conserved parvalbumin genomic clusters carry pvalb-beta 1 and beta 2 copies, whereas pvalb-alpha genes are located separately in different linkage groups. Further, we investigated parvalbumin gene expression in 17 tissues of the common carp (Cyprinus carpio), a species with 21 parvalbumin genes in its genome. Two pvalb-alpha and eight pvalb-beta 2 copies are highly expressed in the muscle, while two alternative pvalb-alpha copies show expression in the brain and the testes, and pvalb-beta 1 is dominant in the retina and the kidney. The recent pairs of muscular pvalb-beta 2 genes show differential expression in this species. We provide robust genomic evidence of the complex evolution of the parvalbumin genes in fishes.

Název v anglickém jazyce

Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication

Popis výsledku anglicky

Parvalbumin is considered a major fish allergen. Here, we report the molecular evolution of the parvalbumin genes in bony fishes based on 19 whole genomes and 70 transcriptomes. We found unexpectedly high parvalbumin diversity in teleosts, three main gene types (pvalb-alpha, pvalb-beta 1, and pvalb-beta 2, including oncomodulins) originated at the onset of vertebrates. Teleosts have further multiplied the parvalbumin gene repertoire up to nine ancestral copies-two copies of pvalb-alpha, two copies of pvalb-beta 1, and five copies of pvalb-beta 2. This gene diversity is a result of teleost-specific whole-genome duplication. Two conserved parvalbumin genomic clusters carry pvalb-beta 1 and beta 2 copies, whereas pvalb-alpha genes are located separately in different linkage groups. Further, we investigated parvalbumin gene expression in 17 tissues of the common carp (Cyprinus carpio), a species with 21 parvalbumin genes in its genome. Two pvalb-alpha and eight pvalb-beta 2 copies are highly expressed in the muscle, while two alternative pvalb-alpha copies show expression in the brain and the testes, and pvalb-beta 1 is dominant in the retina and the kidney. The recent pairs of muscular pvalb-beta 2 genes show differential expression in this species. We provide robust genomic evidence of the complex evolution of the parvalbumin genes in fishes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fishes

ISSN

2410-3888

e-ISSN

2410-3888

Svazek periodika

6

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

70

Kód UT WoS článku

000737137800001

EID výsledku v databázi Scopus

2-s2.0-85121284927