Microglia-mediated degradation of perineuronal nets promotes pain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00566878" target="_blank" >RIV/68378041:_____/22:00566878 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.science.org/doi/10.1126/science.abl6773" target="_blank" >https://www.science.org/doi/10.1126/science.abl6773</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/science.abl6773" target="_blank" >10.1126/science.abl6773</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microglia-mediated degradation of perineuronal nets promotes pain

Popis výsledku v původním jazyce

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets ( PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.

Název v anglickém jazyce

Microglia-mediated degradation of perineuronal nets promotes pain

Popis výsledku anglicky

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets ( PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science

ISSN

0036-8075

e-ISSN

1095-9203

Svazek periodika

377

Číslo periodika v rámci svazku

6601

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

80-86

Kód UT WoS článku

000822009800046

EID výsledku v databázi Scopus

2-s2.0-85133903131