Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00566908" target="_blank" >RIV/68378041:_____/22:00566908 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/22:00563715 RIV/68378041:_____/22:00563715 RIV/60461373:22310/22:43925563 RIV/00216208:11310/22:10455075

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fncel.2022.1025012/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fncel.2022.1025012/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fncel.2022.1025012" target="_blank" >10.3389/fncel.2022.1025012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics

Popis výsledku v původním jazyce

Oligodendrocytes (OL) have been for decades considered a passive, homogenous population of cells that provide support to neurons, and show a limited response to pathological stimuli. This view has been dramatically changed by the introduction of powerful transcriptomic methods that have uncovered a broad spectrum of OL populations that co-exist within the healthy central nervous system (CNS) and also across a variety of diseases. Specifically, single-cell and single-nucleus RNA-sequencing (scRNA-seq, snRNA-seq) have been used to reveal OL variations in maturation, myelination and immune status. The newly discovered immunomodulatory role suggests that OL may serve as targets for future therapies. In this review, we summarize the current understanding of OL heterogeneity in mammalian CNS as revealed by scRNA-seq and snRNA-seq. We provide a list of key studies that identify consensus marker genes defining the currently known OL populations. This resource can be used to standardize analysis of OL related datasets and improve their interpretation, ultimately leading to a better understanding of OL functions in health and disease.

Název v anglickém jazyce

Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics

Popis výsledku anglicky

Oligodendrocytes (OL) have been for decades considered a passive, homogenous population of cells that provide support to neurons, and show a limited response to pathological stimuli. This view has been dramatically changed by the introduction of powerful transcriptomic methods that have uncovered a broad spectrum of OL populations that co-exist within the healthy central nervous system (CNS) and also across a variety of diseases. Specifically, single-cell and single-nucleus RNA-sequencing (scRNA-seq, snRNA-seq) have been used to reveal OL variations in maturation, myelination and immune status. The newly discovered immunomodulatory role suggests that OL may serve as targets for future therapies. In this review, we summarize the current understanding of OL heterogeneity in mammalian CNS as revealed by scRNA-seq and snRNA-seq. We provide a list of key studies that identify consensus marker genes defining the currently known OL populations. This resource can be used to standardize analysis of OL related datasets and improve their interpretation, ultimately leading to a better understanding of OL functions in health and disease.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Cellular Neuroscience

ISSN

1662-5102

e-ISSN

1662-5102

Svazek periodika

16

Číslo periodika v rámci svazku

oct.

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

1025012

Kód UT WoS článku

000875842100001

EID výsledku v databázi Scopus

2-s2.0-85140777633