Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00579627" target="_blank" >RIV/68378041:_____/23:00579627 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11140/23:10469176 RIV/00216208:11110/23:10469176
Výsledek na webu
<a href="https://www.nature.com/articles/s41416-023-02312-z" target="_blank" >https://www.nature.com/articles/s41416-023-02312-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41416-023-02312-z" target="_blank" >10.1038/s41416-023-02312-z</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses
Popis výsledku v původním jazyce
BackgroundDiabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.MethodsWe used data from 3 genetic consortia (CCFR, CORECT, GECCO, 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom, d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).ResultsBased on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - ORAA: 1.62, 95% CI: 1.34-1.96, ORAG: 1.41, 95% CI: 1.30-1.54, ORGG: 1.22, 95% CI: 1.13-1.31, p-value(3-d.f.): 5.46 x 10(-11)) and 13q14.13 (rs9526201, LRCH1 - ORGG: 2.11, 95% CI: 1.56-2.83, ORGA: 1.52, 95% CI: 1.38-1.68, ORAA: 1.13, 95% CI: 1.06-1.21, p-value(2-d.f.): 7.84 x 10(-09)).DiscussionThese results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
Název v anglickém jazyce
Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses
Popis výsledku anglicky
BackgroundDiabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.MethodsWe used data from 3 genetic consortia (CCFR, CORECT, GECCO, 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom, d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).ResultsBased on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - ORAA: 1.62, 95% CI: 1.34-1.96, ORAG: 1.41, 95% CI: 1.30-1.54, ORGG: 1.22, 95% CI: 1.13-1.31, p-value(3-d.f.): 5.46 x 10(-11)) and 13q14.13 (rs9526201, LRCH1 - ORGG: 2.11, 95% CI: 1.56-2.83, ORGA: 1.52, 95% CI: 1.38-1.68, ORAA: 1.13, 95% CI: 1.06-1.21, p-value(2-d.f.): 7.84 x 10(-09)).DiscussionThese results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30101 - Human genetics
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
British Journal of Cancer
ISSN
0007-0920
e-ISSN
1532-1827
Svazek periodika
129
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
10
Strana od-do
511-520
Kód UT WoS článku
001023567900001
EID výsledku v databázi Scopus
2-s2.0-85162876788