Differences in auditory temporal processing in the left and right auditory cortices of the rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00580358" target="_blank" >RIV/68378041:_____/23:00580358 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21730/23:00364275 RIV/00216208:11120/23:43925137

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0378595523000205?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0378595523000205?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.heares.2023.108708" target="_blank" >10.1016/j.heares.2023.108708</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Differences in auditory temporal processing in the left and right auditory cortices of the rat

Popis výsledku v původním jazyce

In the present study, we examined hemispheric differences in the representation and processing of tem-porally structured auditory stimuli. Neuronal responses evoked by sinusoidally frequency modulated (FM) tones, frequency sweeps, amplitude modulated (AM) tones and noise, click trains with constant inter-click intervals and natural vocalizations were recorded from the left (LAC) and right (RAC) auditory cortices in adult (4-6 months old) anaesthetized F344 rats. Using vector strength, modulation-transfer functions, van Rossum distances, or direction-selectivity index, representation and processing of structured audi-tory stimuli were compared in the LAC and the RAC. The RAC generally tended to exhibit a higher abil-ity to synchronize with the stimulus, a higher reproducibility of responses, and a higher proportion of direction-selective units. The LAC, on the other hand, mostly had higher relative response magnitudes in the modulation transfer functions. Importantly, the hemispheric differences were dependent on the type of the stimulus and there was also a significant inter-individual variability. Our findings indicate that neural coding in the RAC is based more on timing of action potentials (temporal code), while the LAC uses more the response magnitudes (rate code). It is thus necessary to distinguish between the type of the neural code and the stimulus feature it encodes and reconsider the simple opinion about dominance of the LAC for temporal processing, as it may not hold in general for all types of temporally structured stimuli.(c) 2023 Published by Elsevier B.V.

Název v anglickém jazyce

Differences in auditory temporal processing in the left and right auditory cortices of the rat

Popis výsledku anglicky

In the present study, we examined hemispheric differences in the representation and processing of tem-porally structured auditory stimuli. Neuronal responses evoked by sinusoidally frequency modulated (FM) tones, frequency sweeps, amplitude modulated (AM) tones and noise, click trains with constant inter-click intervals and natural vocalizations were recorded from the left (LAC) and right (RAC) auditory cortices in adult (4-6 months old) anaesthetized F344 rats. Using vector strength, modulation-transfer functions, van Rossum distances, or direction-selectivity index, representation and processing of structured audi-tory stimuli were compared in the LAC and the RAC. The RAC generally tended to exhibit a higher abil-ity to synchronize with the stimulus, a higher reproducibility of responses, and a higher proportion of direction-selective units. The LAC, on the other hand, mostly had higher relative response magnitudes in the modulation transfer functions. Importantly, the hemispheric differences were dependent on the type of the stimulus and there was also a significant inter-individual variability. Our findings indicate that neural coding in the RAC is based more on timing of action potentials (temporal code), while the LAC uses more the response magnitudes (rate code). It is thus necessary to distinguish between the type of the neural code and the stimulus feature it encodes and reconsider the simple opinion about dominance of the LAC for temporal processing, as it may not hold in general for all types of temporally structured stimuli.(c) 2023 Published by Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LTAIN19201" target="_blank" >LTAIN19201: Zpracování komplexních akustických signálů včetně vokalizací v inhibičních okruzích centrálního sluchového systému u myších modelů autismu a různých typů senzorineurální ztráty sluchu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hearing Research

ISSN

0378-5955

e-ISSN

1878-5891

Svazek periodika

430

Číslo periodika v rámci svazku

feb

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

108708

Kód UT WoS článku

000963976800001

EID výsledku v databázi Scopus

2-s2.0-85147333941