Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00580369" target="_blank" >RIV/68378041:_____/23:00580369 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10456129

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S088723332200234X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S088723332200234X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tiv.2022.105536" target="_blank" >10.1016/j.tiv.2022.105536</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells

Popis výsledku v původním jazyce

Nanoparticles (NPs) have a wide use in various field of industry and in medicine, where they represent a promise for their antimicrobial effects. Simultaneous application of NPs and therapeutic stem cells can speed up tissue regeneration and improve healing process but there is a danger of negative impacts of NPs on stem cells. Therefore, we tested effects of four types of metal antimicrobial NPs on characteristics and function properties of mouse mesenchymal stem cells (MSCs) in vitro. All types of tested NPs, i.e. zinc oxide, silver, copper oxide and titanium dioxide, exerted negative effects on the expression of phenotypic markers, metabolic activity, differ-entiation potential, expression of genes for immunoregulatory molecules and on production of cytokines and growth factors by MSCs. However, there were apparent differences in the impact of individual types of NPs on tested characteristics and function properties of MSCs. The results showed that individual types of NPs influence the activity of MSCs, and thus the use of metal NPs during tissue regeneration and in combination with stem cell therapy should be well considered.

Název v anglickém jazyce

Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells

Popis výsledku anglicky

Nanoparticles (NPs) have a wide use in various field of industry and in medicine, where they represent a promise for their antimicrobial effects. Simultaneous application of NPs and therapeutic stem cells can speed up tissue regeneration and improve healing process but there is a danger of negative impacts of NPs on stem cells. Therefore, we tested effects of four types of metal antimicrobial NPs on characteristics and function properties of mouse mesenchymal stem cells (MSCs) in vitro. All types of tested NPs, i.e. zinc oxide, silver, copper oxide and titanium dioxide, exerted negative effects on the expression of phenotypic markers, metabolic activity, differ-entiation potential, expression of genes for immunoregulatory molecules and on production of cytokines and growth factors by MSCs. However, there were apparent differences in the impact of individual types of NPs on tested characteristics and function properties of MSCs. The results showed that individual types of NPs influence the activity of MSCs, and thus the use of metal NPs during tissue regeneration and in combination with stem cell therapy should be well considered.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/GA21-17720S" target="_blank" >GA21-17720S: Vliv nanočástic kovů na vlastnosti a funkce kmenových buněk: studie in vitro a in vivo</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology in Vitro

ISSN

0887-2333

e-ISSN

1879-3177

Svazek periodika

87

Číslo periodika v rámci svazku

mar

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

105536

Kód UT WoS článku

000910075000001

EID výsledku v databázi Scopus

2-s2.0-85144298955