Genetic and non-genetic risk factors for early-onset pancreatic cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00581913" target="_blank" >RIV/68378041:_____/23:00581913 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10458464 RIV/00216208:11120/23:43925300 RIV/00216208:11140/23:10458464 RIV/00064173:_____/23:43925300 a 2 dalších

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1590865823005145?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1590865823005145?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dld.2023.02.023" target="_blank" >10.1016/j.dld.2023.02.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genetic and non-genetic risk factors for early-onset pancreatic cancer

Popis výsledku v původním jazyce

Background: Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC. Methods: A genome-wide association study was performed, analysing 912 EOPC cases and 10 222 controls, divided into discovery and replication phases. Furthermore, the associations between a polygenic risk score (PRS), smoking, alcohol consumption, type 2 diabetes and PDAC risk were also assessed. Results: Six novel SNPs were associated with EOPC risk in the discovery phase, but not in the replication phase. The PRS, smoking, and diabetes affected EOPC risk. The OR comparing current smokers to never smokers was 2.92 (95% CI 1.69-5.04, P = 1.44 x 10 -4). For diabetes, the corresponding OR was 14.95 (95% CI 3.41-65.50, P = 3.58 x 10 -4). Conclusion: In conclusion, we did not identify novel genetic variants associated specifically with EOPC, and we found that established PDAC risk variants do not have a strong age-dependent effect. Furthermore, we add to the evidence pointing to the role of smoking and diabetes in EOPC. (c) 2023 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Název v anglickém jazyce

Genetic and non-genetic risk factors for early-onset pancreatic cancer

Popis výsledku anglicky

Background: Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC. Methods: A genome-wide association study was performed, analysing 912 EOPC cases and 10 222 controls, divided into discovery and replication phases. Furthermore, the associations between a polygenic risk score (PRS), smoking, alcohol consumption, type 2 diabetes and PDAC risk were also assessed. Results: Six novel SNPs were associated with EOPC risk in the discovery phase, but not in the replication phase. The PRS, smoking, and diabetes affected EOPC risk. The OR comparing current smokers to never smokers was 2.92 (95% CI 1.69-5.04, P = 1.44 x 10 -4). For diabetes, the corresponding OR was 14.95 (95% CI 3.41-65.50, P = 3.58 x 10 -4). Conclusion: In conclusion, we did not identify novel genetic variants associated specifically with EOPC, and we found that established PDAC risk variants do not have a strong age-dependent effect. Furthermore, we add to the evidence pointing to the role of smoking and diabetes in EOPC. (c) 2023 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Digestive and Liver Disease

ISSN

1590-8658

e-ISSN

1878-3562

Svazek periodika

55

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1417-1425

Kód UT WoS článku

001084748400001

EID výsledku v databázi Scopus

2-s2.0-85151481167