Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00583165" target="_blank" >RIV/68378041:_____/23:00583165 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/22:43925155 RIV/00064203:_____/23:10442868

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/10255842.2022.2058875" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10255842.2022.2058875</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10255842.2022.2058875" target="_blank" >10.1080/10255842.2022.2058875</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes

Popis výsledku v původním jazyce

nTitanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a model that explains cell adhesion to a nanostructured surface by considering the deformation energy of cell protrusions into titanium nanotubes and the adhesion to the surface. The optimal surface topology is defined as a geometry that gives the membrane a minimum energy shape. A dimensionless parameter, the cell interaction index, was proposed to describe the interplay between the cell membrane bending, the intrinsic curvature, and the strength of cell adhesion. Model simulation shows that an optimal nanotube diameter ranging from 20 nm to 100 nm (cell interaction index between 0.2 and 1, respectively) is feasible within a certain range of parameters describing cell membrane adhesion and bending. The results indicate a possibility to tune the topology of a nanostructural surface in order to enhance the proliferation and differentiation of cells mechanically compatible with the given surface geometry while suppressing the growth of other mechanically incompatible cells.

Název v anglickém jazyce

Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes

Popis výsledku anglicky

nTitanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a model that explains cell adhesion to a nanostructured surface by considering the deformation energy of cell protrusions into titanium nanotubes and the adhesion to the surface. The optimal surface topology is defined as a geometry that gives the membrane a minimum energy shape. A dimensionless parameter, the cell interaction index, was proposed to describe the interplay between the cell membrane bending, the intrinsic curvature, and the strength of cell adhesion. Model simulation shows that an optimal nanotube diameter ranging from 20 nm to 100 nm (cell interaction index between 0.2 and 1, respectively) is feasible within a certain range of parameters describing cell membrane adhesion and bending. The results indicate a possibility to tune the topology of a nanostructural surface in order to enhance the proliferation and differentiation of cells mechanically compatible with the given surface geometry while suppressing the growth of other mechanically incompatible cells.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Computer methods in biomechanics and biomedical engineering

ISSN

1025-5842

e-ISSN

1476-8259

Svazek periodika

26

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

281-290

Kód UT WoS článku

000778467000001

EID výsledku v databázi Scopus

2-s2.0-85128231530