Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00584709" target="_blank" >RIV/68378041:_____/23:00584709 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2090123223000061?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2090123223000061?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jare.2023.01.006" target="_blank" >10.1016/j.jare.2023.01.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Popis výsledku v původním jazyce

Background: Synaptic dysfunction is a major contributor to Alzheimer ' s disease (AD) pathogenesis in addition to the formation of neuritic b-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features contribute to synaptic dysfunction and axonal loss remains unclear. While years of considerable effort have been devoted to gaining an improved under -standing of this devastating disease, the unavailability of patient-derived tissues, considerable genetic heterogeneity, and lack of animal models that faithfully recapitulate human AD have hampered the development of effective treatment options. Ongoing progress in human induced pluripotent stem cell (hiPSC) technology has permitted the derivation of patient-and disease-specific stem cells with unlim-ited self-renewal capacity. These cells can differentiate into AD-affected cell types, which support studies of disease mechanisms, drug discovery, and the development of cell replacement therapies in traditional and advanced cell culture models.Aim of Review: To summarize current hiPSC-based AD models, highlighting the associated achievements and challenges with a primary focus on neuron and synapse loss.Key Scientific Concepts of Review: We aim to identify how hiPSC models can contribute to understanding AD-associated synaptic dysfunction and axonal loss. hiPSC-derived neural cells, astrocytes, and microglia, as well as more sophisticated cellular organoids, may represent reliable models to investigate AD and identify early markers of AD-associated neural degeneration.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

Název v anglickém jazyce

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Popis výsledku anglicky

Background: Synaptic dysfunction is a major contributor to Alzheimer ' s disease (AD) pathogenesis in addition to the formation of neuritic b-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features contribute to synaptic dysfunction and axonal loss remains unclear. While years of considerable effort have been devoted to gaining an improved under -standing of this devastating disease, the unavailability of patient-derived tissues, considerable genetic heterogeneity, and lack of animal models that faithfully recapitulate human AD have hampered the development of effective treatment options. Ongoing progress in human induced pluripotent stem cell (hiPSC) technology has permitted the derivation of patient-and disease-specific stem cells with unlim-ited self-renewal capacity. These cells can differentiate into AD-affected cell types, which support studies of disease mechanisms, drug discovery, and the development of cell replacement therapies in traditional and advanced cell culture models.Aim of Review: To summarize current hiPSC-based AD models, highlighting the associated achievements and challenges with a primary focus on neuron and synapse loss.Key Scientific Concepts of Review: We aim to identify how hiPSC models can contribute to understanding AD-associated synaptic dysfunction and axonal loss. hiPSC-derived neural cells, astrocytes, and microglia, as well as more sophisticated cellular organoids, may represent reliable models to investigate AD and identify early markers of AD-associated neural degeneration.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Centrum rekonstrukčních neurověd</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Advanced Research

ISSN

2090-1232

e-ISSN

2090-1224

Svazek periodika

54

Číslo periodika v rámci svazku

dec.

Stát vydavatele periodika

EG - Egyptská arabská republika

Počet stran výsledku

14

Strana od-do

105-118

Kód UT WoS článku

001127856800001

EID výsledku v databázi Scopus

2-s2.0-85147128554