Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00598841" target="_blank" >RIV/68378041:_____/24:00598841 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41583-024-00849-3" target="_blank" >https://www.nature.com/articles/s41583-024-00849-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41583-024-00849-3" target="_blank" >10.1038/s41583-024-00849-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

Popis výsledku v původním jazyce

Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.

Název v anglickém jazyce

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

Popis výsledku anglicky

Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Reviews Neuroscience

ISSN

1471-003X

e-ISSN

1471-0048

Svazek periodika

25

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

19

Strana od-do

649-667

Kód UT WoS článku

001295024600001

EID výsledku v databázi Scopus

2-s2.0-85201608153