Hybrid organosilane nanofibre scaffold formation supporting cell adhesion and growth

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00600340" target="_blank" >RIV/68378041:_____/24:00600340 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/24:00600340 RIV/46747885:24410/24:00012621 RIV/46747885:24510/24:00012621 RIV/46747885:24620/24:00012621 RIV/00216208:11310/24:10497580

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s10853-024-10324-0" target="_blank" >https://link.springer.com/article/10.1007/s10853-024-10324-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10853-024-10324-0" target="_blank" >10.1007/s10853-024-10324-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hybrid organosilane nanofibre scaffold formation supporting cell adhesion and growth

Popis výsledku v původním jazyce

Hybrid organic–inorganic nanomaterials made of various types of organosilanes display very promising applications in a variety of fields, including biocompatible materials. Currently, these types of nanomaterials are studied in various physical forms due to the tunable combination of organic and inorganic parts bringing numerous properties into the field of medicine. Particularly, in the field of regenerative medicine, nanofibrous organosilane scaffolds are under wide investigation due to their morphological similarity to the extracellular matrix. Here, we describe the economically and procedurally simple synthesis and successful preparation of pure organosilane nanofibres (NFs) using only an N,N´-bis(3-(triethoxysilyl)propyl)oxamide precursor via a one-pot synthesis process utilising the acid-catalysed sol–gel process. Unlike established practices, the organosilane scaffolds proposed in this work are prepared thanks to the conscious and precise setting of the sol–gel process parameters without the need for any potentially harmful additives such as co-polymers, surfactants, and/or alkoxides. In addition, the synthesis of the precursor (BTPO) contains silicates for the polymerisation and a simple organic alkyl linker with amide bonds being akin to the biological friendly peptide bond. BTPO NFs were successfully electrospun on a large scale using a Nanospider™ and fully characterised and analysed for cytocompatibility using 3T3 fibroblasts. Formed organosilane NFs displaying negligible cytotoxicity, along with good cell proliferation and metabolic activity, open up the possibility of introducing various organic structures, using the synthetic strategies presented here, for inherent functional properties which could be exploited further in tissue engineering.

Název v anglickém jazyce

Hybrid organosilane nanofibre scaffold formation supporting cell adhesion and growth

Popis výsledku anglicky

Hybrid organic–inorganic nanomaterials made of various types of organosilanes display very promising applications in a variety of fields, including biocompatible materials. Currently, these types of nanomaterials are studied in various physical forms due to the tunable combination of organic and inorganic parts bringing numerous properties into the field of medicine. Particularly, in the field of regenerative medicine, nanofibrous organosilane scaffolds are under wide investigation due to their morphological similarity to the extracellular matrix. Here, we describe the economically and procedurally simple synthesis and successful preparation of pure organosilane nanofibres (NFs) using only an N,N´-bis(3-(triethoxysilyl)propyl)oxamide precursor via a one-pot synthesis process utilising the acid-catalysed sol–gel process. Unlike established practices, the organosilane scaffolds proposed in this work are prepared thanks to the conscious and precise setting of the sol–gel process parameters without the need for any potentially harmful additives such as co-polymers, surfactants, and/or alkoxides. In addition, the synthesis of the precursor (BTPO) contains silicates for the polymerisation and a simple organic alkyl linker with amide bonds being akin to the biological friendly peptide bond. BTPO NFs were successfully electrospun on a large scale using a Nanospider™ and fully characterised and analysed for cytocompatibility using 3T3 fibroblasts. Formed organosilane NFs displaying negligible cytotoxicity, along with good cell proliferation and metabolic activity, open up the possibility of introducing various organic structures, using the synthetic strategies presented here, for inherent functional properties which could be exploited further in tissue engineering.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Science

ISSN

0022-2461

e-ISSN

1573-4803

Svazek periodika

59

Číslo periodika v rámci svazku

41

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

16

Strana od-do

19612-19627

Kód UT WoS článku

001340554100002

EID výsledku v databázi Scopus

2-s2.0-85207209923