Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00603829" target="_blank" >RIV/68378041:_____/24:00603829 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10481671 RIV/00216208:11120/24:43927295 RIV/00216208:11140/24:10481671 RIV/00064173:_____/24:43927295 RIV/00098892:_____/24:10158736

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/ijc.35046" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ijc.35046</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijc.35046" target="_blank" >10.1002/ijc.35046</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk

Popis výsledku v původním jazyce

Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10−5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer, however, functional studies are needed to elucidate the function relevance of the association.

Název v anglickém jazyce

Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk

Popis výsledku anglicky

Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10−5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer, however, functional studies are needed to elucidate the function relevance of the association.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NU21-03-00499" target="_blank" >NU21-03-00499: Prospektivní studie na včasnou detekci karcinomu pankreatu a sledování průběhu léčby na základě lipidomického profilování hmotnostní spektrometrií</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cancer

ISSN

0020-7136

e-ISSN

1097-0215

Svazek periodika

155

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

1432-1442

Kód UT WoS článku

001254858600001

EID výsledku v databázi Scopus

2-s2.0-85197257437