Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00601685" target="_blank" >RIV/68378041:_____/25:00601685 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00140932 RIV/00216208:11310/25:10515634

Výsledek na webu

<a href="https://elifesciences.org/articles/100854" target="_blank" >https://elifesciences.org/articles/100854</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.100854.1" target="_blank" >10.7554/eLife.100854.1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

Popis výsledku v původním jazyce

Hair follicle development is initiated by reciprocal molecular interactions between the placode-forming epithelium and the underlying mesenchyme. Cell fate transformation in dermal fibroblasts generates cell niche for placode induction by activation of signaling pathways WNT, EDA and FGF in epithelium. These successive paracrine epithelial signals initiate dermal condensation in the underlying mesenchyme. Although epithelial signaling from the placode to mesenchyme is better described, little is known about primary mesenchymal signals resulting in placode induction. Here we show that Meis2 expression in cells derived from the neural crest is critical for whisker formation, and also for branching of trigeminal nerves. While whisker formation is independent of the trigeminal sensory innervation, MEIS2 in mesenchymal dermal cells orchestrates initial steps of epithelial placode formation and subsequent dermal condensation. MEIS2 regulates the expression of transcription factor Foxd1 which is typical of pre-dermal condensation. However, deletion of Foxd1 does not affect whisker development. Overall, our data report an early role of mesenchymal MEIS2 during whisker formation and provide evidence that whiskers can normally develop in the absence of sensory innervation or FOXD1 expression.

Název v anglickém jazyce

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

Popis výsledku anglicky

Hair follicle development is initiated by reciprocal molecular interactions between the placode-forming epithelium and the underlying mesenchyme. Cell fate transformation in dermal fibroblasts generates cell niche for placode induction by activation of signaling pathways WNT, EDA and FGF in epithelium. These successive paracrine epithelial signals initiate dermal condensation in the underlying mesenchyme. Although epithelial signaling from the placode to mesenchyme is better described, little is known about primary mesenchymal signals resulting in placode induction. Here we show that Meis2 expression in cells derived from the neural crest is critical for whisker formation, and also for branching of trigeminal nerves. While whisker formation is independent of the trigeminal sensory innervation, MEIS2 in mesenchymal dermal cells orchestrates initial steps of epithelial placode formation and subsequent dermal condensation. MEIS2 regulates the expression of transcription factor Foxd1 which is typical of pre-dermal condensation. However, deletion of Foxd1 does not affect whisker development. Overall, our data report an early role of mesenchymal MEIS2 during whisker formation and provide evidence that whiskers can normally develop in the absence of sensory innervation or FOXD1 expression.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

eLife

ISSN

2050-084X

e-ISSN

2050-084X

Svazek periodika

13

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

21

Strana od-do

RP100854

Kód UT WoS článku

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EID výsledku v databázi Scopus

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