Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00636275" target="_blank" >RIV/68378041:_____/25:00636275 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10497867 RIV/00216208:11140/25:10497867 RIV/00216208:11310/25:10497867 RIV/00098892:_____/25:10159263

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1044579X25000628?via%3Dihub#ack0005" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1044579X25000628?via%3Dihub#ack0005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.semcancer.2025.05.005" target="_blank" >10.1016/j.semcancer.2025.05.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer

Popis výsledku v původním jazyce

Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent genomic instability in cancer cells. The latter comprises a) DNA damage response and DNA repair mechanisms, b) DNA replication and mitosis, c) epigenetic regulation, and d) telomere maintenance. In our review we addressed the above aspects in relation to the most abundant and severe form of PC, pancreatic ductal adenocarcinoma (PDAC). In summary, the interactions between the DNA damage response, telomere homeostasis and mitotic regulation are not comprehensively understood at present, including the epigenetic factors entering the trait of genomic stability maintenance. In addition, the complexity of telomere homeostasis in relation to PDAC risk, prognosis and prediction also warrants further investigations.

Název v anglickém jazyce

Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer

Popis výsledku anglicky

Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent genomic instability in cancer cells. The latter comprises a) DNA damage response and DNA repair mechanisms, b) DNA replication and mitosis, c) epigenetic regulation, and d) telomere maintenance. In our review we addressed the above aspects in relation to the most abundant and severe form of PC, pancreatic ductal adenocarcinoma (PDAC). In summary, the interactions between the DNA damage response, telomere homeostasis and mitotic regulation are not comprehensively understood at present, including the epigenetic factors entering the trait of genomic stability maintenance. In addition, the complexity of telomere homeostasis in relation to PDAC risk, prognosis and prediction also warrants further investigations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NU21-07-00247" target="_blank" >NU21-07-00247: Využití konceptu tekuté biopsie pro charakterizaci mikroRNA a onkogenní KRAS mutace pro stanovení včasné diagnózy a zhodnocení rizika vzniku karcinomu pankreatu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

SEMINARS IN CANCER BIOLOGY

ISSN

1044-579X

e-ISSN

1096-3650

Svazek periodika

113

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

59-73

Kód UT WoS článku

001493177500001

EID výsledku v databázi Scopus

2-s2.0-105005177400