Characterization and bioactivity of β-tricalcium phosphate powder sol-gel coatings on titanium substrates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00639597" target="_blank" >RIV/68378041:_____/25:00639597 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21220/25:00385459 RIV/60076658:12520/25:43910079

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s10971-025-06918-y" target="_blank" >https://link.springer.com/article/10.1007/s10971-025-06918-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10971-025-06918-y" target="_blank" >10.1007/s10971-025-06918-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization and bioactivity of β-tricalcium phosphate powder sol-gel coatings on titanium substrates

Popis výsledku v původním jazyce

The proliferation, differentiation or viability of cells on a bioactive surface such as ß-tricalcium phosphate (ß-TCP) is a key aspect of regenerative medicine and biomaterials research. In this study, a sol-gel solution specifically developed for biomaterial applications was used, into which crystalline ß-tricalcium phosphate (ß-TCP) powder was added at various concentrations. This approach differs from conventional methods where ß-TCP is synthesized directly within the sol–gel matrix. The direct incorporation of powder into the base sol allows for better control over particle distribution and size, influencing the morphology, mechanical properties, and biological activity of coatings applied to titanium substrates. The surfaces were characterized in terms of changes in roughness, wettability, and mechanical parameters. Biological tests with the MG63 cell line showed increased cell proliferation and adhesion, particularly during the first 48 h of cultivation, confirming the bioactive effect of the added ß-TCP powder. These results suggest the potential of this approach for developing bioactive coatings on titanium implants with improved osseointegration and stability.

Název v anglickém jazyce

Characterization and bioactivity of β-tricalcium phosphate powder sol-gel coatings on titanium substrates

Popis výsledku anglicky

The proliferation, differentiation or viability of cells on a bioactive surface such as ß-tricalcium phosphate (ß-TCP) is a key aspect of regenerative medicine and biomaterials research. In this study, a sol-gel solution specifically developed for biomaterial applications was used, into which crystalline ß-tricalcium phosphate (ß-TCP) powder was added at various concentrations. This approach differs from conventional methods where ß-TCP is synthesized directly within the sol–gel matrix. The direct incorporation of powder into the base sol allows for better control over particle distribution and size, influencing the morphology, mechanical properties, and biological activity of coatings applied to titanium substrates. The surfaces were characterized in terms of changes in roughness, wettability, and mechanical parameters. Biological tests with the MG63 cell line showed increased cell proliferation and adhesion, particularly during the first 48 h of cultivation, confirming the bioactive effect of the added ß-TCP powder. These results suggest the potential of this approach for developing bioactive coatings on titanium implants with improved osseointegration and stability.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20506 - Coating and films

Projekt

<a href="/cs/project/LM2023050" target="_blank" >LM2023050: Národní infrastruktura pro biologické a medicínské zobrazování</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Sol-Gel Science and Technology

ISSN

0928-0707

e-ISSN

1573-4846

Svazek periodika

116

Číslo periodika v rámci svazku

11/2025

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

1304-1315

Kód UT WoS článku

001571173700001

EID výsledku v databázi Scopus

2-s2.0-105016236664