Letter to the Editor Rebuttal to Qi et al. (2025): Alpha 9 integrin in spinal cord repair: a critical appraisal of mechanisms, circuitry, and translational potential

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00644520" target="_blank" >RIV/68378041:_____/25:00644520 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1186/s40478-025-02186-7" target="_blank" >https://link.springer.com/article/10.1186/s40478-025-02186-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40478-025-02186-7" target="_blank" >10.1186/s40478-025-02186-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Letter to the Editor Rebuttal to Qi et al. (2025): Alpha 9 integrin in spinal cord repair: a critical appraisal of mechanisms, circuitry, and translational potential

Popis výsledku v původním jazyce

In response to the commentary by Qi et al. (2025) on our recent study of alpha 9 integrin in spinal cord repair, we provide clarifications on several factual and interpretative points. The alpha 9 integrin binding site resides within the third fibronectin type III-like repeat of tenascin-C, which is not alternatively spliced, ensuring consistent ligand engagement. Multiple studies, including those by Dobbertin et al., Cimpean et al., and Tan et al. support the pro-regenerative role of alpha 9 integrin and its ability to overcome CSPG-mediated inhibition through Src and FAK signalling. We further note that long-term studies are indeed warranted and have facilitated such research by depositing all constructs on Addgene. Contrary to the commentarys claim, our study employed a spinal cord injury model, not a dorsal root crush, and histological data confirm the presence of a fibrotic scar. No evidence of neuropathic pain was observed at 12 weeks, indicating functional safety within the study timeframe. Together, these clarifications reaffirm that alpha 9 integrin signalling directly promotes axon regeneration and that future work using temporally controlled systems will build on these findings.

Název v anglickém jazyce

Letter to the Editor Rebuttal to Qi et al. (2025): Alpha 9 integrin in spinal cord repair: a critical appraisal of mechanisms, circuitry, and translational potential

Popis výsledku anglicky

In response to the commentary by Qi et al. (2025) on our recent study of alpha 9 integrin in spinal cord repair, we provide clarifications on several factual and interpretative points. The alpha 9 integrin binding site resides within the third fibronectin type III-like repeat of tenascin-C, which is not alternatively spliced, ensuring consistent ligand engagement. Multiple studies, including those by Dobbertin et al., Cimpean et al., and Tan et al. support the pro-regenerative role of alpha 9 integrin and its ability to overcome CSPG-mediated inhibition through Src and FAK signalling. We further note that long-term studies are indeed warranted and have facilitated such research by depositing all constructs on Addgene. Contrary to the commentarys claim, our study employed a spinal cord injury model, not a dorsal root crush, and histological data confirm the presence of a fibrotic scar. No evidence of neuropathic pain was observed at 12 weeks, indicating functional safety within the study timeframe. Together, these clarifications reaffirm that alpha 9 integrin signalling directly promotes axon regeneration and that future work using temporally controlled systems will build on these findings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Neuropathologica Communications

ISSN

2051-5960

e-ISSN

2051-5960

Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

2

Strana od-do

261

Kód UT WoS článku

001650867400001

EID výsledku v databázi Scopus

2-s2.0-105026154901