Délková distribuce retroelementů LINE a procesovaných pseudogenů lidských endogenních retrovirů: implikace pro retrotranspozici a detekci pseudogenů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F02%3A00108985" target="_blank" >RIV/68378050:_____/02:00108985 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Length distribution of long interspersed nuclear elements (LINEs) and processed pseudogenes of human endogenous retroviruses: implications for retrotransposition and pseudogene detection

Popis výsledku v původním jazyce

We have analyzed the length distribution of LINEs and of processed pseudogenes derived from HERV-W. As expected, we have found that the majority of 5´ truncated LINEs and HERV-W processed pseudogenes show a prevalence of very short elements terminated close to the 3´ end. On the other hand, the number of complete elements is far above the expectation. The characteristic distribution in both cases indicates two important conclusions: (i) dissociation of LINE RT from the template cannot be fully explainedby low processivity of RT modelled as a stochastic, Poisson-type process. (ii) Currently cited numbers of pseudogenes within the human genome are underestimated, since a large percentage of pseudogenes are terminated in the 3´ untranslated region and remain undetectable in translated homology searches of protein databases against the human genome

Název v anglickém jazyce

Length distribution of long interspersed nuclear elements (LINEs) and processed pseudogenes of human endogenous retroviruses: implications for retrotransposition and pseudogene detection

Popis výsledku anglicky

We have analyzed the length distribution of LINEs and of processed pseudogenes derived from HERV-W. As expected, we have found that the majority of 5´ truncated LINEs and HERV-W processed pseudogenes show a prevalence of very short elements terminated close to the 3´ end. On the other hand, the number of complete elements is far above the expectation. The characteristic distribution in both cases indicates two important conclusions: (i) dissociation of LINE RT from the template cannot be fully explainedby low processivity of RT modelled as a stochastic, Poisson-type process. (ii) Currently cited numbers of pseudogenes within the human genome are underestimated, since a large percentage of pseudogenes are terminated in the 3´ untranslated region and remain undetectable in translated homology searches of protein databases against the human genome

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA204%2F01%2F0632" target="_blank" >GA204/01/0632: Vzorec methylace DNA regulačních sekvencí retrovirů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gene

ISSN

0378-1119

e-ISSN

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Svazek periodika

300

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

246-249

Kód UT WoS článku

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EID výsledku v databázi Scopus

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