Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F02%3A23049036" target="_blank" >RIV/68378050:_____/02:23049036 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/02:00102941 RIV/68378050:_____/02:00191542

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9.

Popis výsledku v původním jazyce

We characterized the mouse PARP-3 gene encoding poly(ADP-ribose) polymerase 3 and the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein. The two genes are located in a head-to-head orientation on mouse chromosome 9 and are linked by an approximately 1.5-kb putative bi-directional promoter region. This gene arrangement is conserved between mouse and human orthologues. Using a panel of mRNAs from various adult mouse tissues and organs,the expression profiles of PARP-3, U3-55k, PARP-2 and PARP-1 genes were determined. PARP-3 expression exhibited marked differences among the individual tissues and some degree of tissue specificity, ranging from the highest transcript levels in the skeletal muscle to the barely detectable expression in the whole=brain and testis mRNA. In contrast to PARP-3, the other three genes were expressed ubiquitously, with less variability of mRNA levels.

Název v anglickém jazyce

Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9.

Popis výsledku anglicky

We characterized the mouse PARP-3 gene encoding poly(ADP-ribose) polymerase 3 and the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein. The two genes are located in a head-to-head orientation on mouse chromosome 9 and are linked by an approximately 1.5-kb putative bi-directional promoter region. This gene arrangement is conserved between mouse and human orthologues. Using a panel of mRNAs from various adult mouse tissues and organs,the expression profiles of PARP-3, U3-55k, PARP-2 and PARP-1 genes were determined. PARP-3 expression exhibited marked differences among the individual tissues and some degree of tissue specificity, ranging from the highest transcript levels in the skeletal muscle to the barely detectable expression in the whole=brain and testis mRNA. In contrast to PARP-3, the other three genes were expressed ubiquitously, with less variability of mRNA levels.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica (Praha)

ISSN

0015-5500

e-ISSN

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Svazek periodika

48

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

182-191

Kód UT WoS článku

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EID výsledku v databázi Scopus

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