Serinové proteinázy a jejich inhibitory při oplodnění

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F04%3A00105287" target="_blank" >RIV/68378050:_____/04:00105287 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Serine proteinases and their inhibitors in fertilization

Popis výsledku v původním jazyce

Mammalian fertilization includes highly regulated biochemical interactions between complementary molecules located on the surfaces of both gametes as well as those present in the gamete natural environment in male and female reproductive tracts. The keyproteinase of the fertilization process is acrosin, localized in the acrosome of the spermatozoon. Acrosin is involved in the acrosome reaction of spermatozoa, in the secondary binding of the sperm to the zona pellucida (ZP) and penetration of the ZP bysperm. The biological role of acrosin inhibitors in sexual fluids is to inactivate the prematurely released active form of acrosin from occasionally damaged spermatozoa. Seminal plasma proteins (spermadhesins) attached to the sperm head are acceptor molecules for the sperm-associated acrosin inhibitor. The attachement of the inhibitor to the surface molecules of the sperm can stabilize the binding site for ZP and protect the sperm against proteolytic degradation

Název v anglickém jazyce

Serine proteinases and their inhibitors in fertilization

Popis výsledku anglicky

Mammalian fertilization includes highly regulated biochemical interactions between complementary molecules located on the surfaces of both gametes as well as those present in the gamete natural environment in male and female reproductive tracts. The keyproteinase of the fertilization process is acrosin, localized in the acrosome of the spermatozoon. Acrosin is involved in the acrosome reaction of spermatozoa, in the secondary binding of the sperm to the zona pellucida (ZP) and penetration of the ZP bysperm. The biological role of acrosin inhibitors in sexual fluids is to inactivate the prematurely released active form of acrosin from occasionally damaged spermatozoa. Seminal plasma proteins (spermadhesins) attached to the sperm head are acceptor molecules for the sperm-associated acrosin inhibitor. The attachement of the inhibitor to the surface molecules of the sperm can stabilize the binding site for ZP and protect the sperm against proteolytic degradation

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomarkers and Environment

ISSN

1211-8869

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

108-110

Kód UT WoS článku

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EID výsledku v databázi Scopus

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