Střevní bakterie jako spouštěcí činitele ankylosující enthesopatie

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F04%3A00109718" target="_blank" >RIV/68378050:_____/04:00109718 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Intestinal bacteria as triggering agents in murine ankylosing enthesopathy

Popis výsledku v původním jazyce

Mouse strain B10:BR spontaneously developing ankylosing enthesopathy (ANKENT)has been used as experimental model for AS (ankylosing spondylitis, joint disease in man). We studied the role of intestinal microflora components as ANKENT-triggering agents. In conventional B10.BR males the prevalence of ANKENT of 10-15% has been observed. In contrast, no affected males were observed under germ-free (GF) conditions. B10:BR GF males were associated with a coctail of bacteria isolated from the intestine. ANKENThas developed in B10.BR male groups associated with different commensal bacterial strains including G+ as well as G- bacteria. Among all experimental groups only Lactobacillus sp.-associated animals have remained all healthy. We have found that a limited cocktail consisting of about 10 of gut-born bacterial strains has been as efficient as CV microflora in ANKENT triggering. Consequently, commensal bacteria play an important role in ANKENT pathogenesis

Název v anglickém jazyce

Intestinal bacteria as triggering agents in murine ankylosing enthesopathy

Popis výsledku anglicky

Mouse strain B10:BR spontaneously developing ankylosing enthesopathy (ANKENT)has been used as experimental model for AS (ankylosing spondylitis, joint disease in man). We studied the role of intestinal microflora components as ANKENT-triggering agents. In conventional B10.BR males the prevalence of ANKENT of 10-15% has been observed. In contrast, no affected males were observed under germ-free (GF) conditions. B10:BR GF males were associated with a coctail of bacteria isolated from the intestine. ANKENThas developed in B10.BR male groups associated with different commensal bacterial strains including G+ as well as G- bacteria. Among all experimental groups only Lactobacillus sp.-associated animals have remained all healthy. We have found that a limited cocktail consisting of about 10 of gut-born bacterial strains has been as efficient as CV microflora in ANKENT triggering. Consequently, commensal bacteria play an important role in ANKENT pathogenesis

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA305%2F03%2F0287" target="_blank" >GA305/03/0287: Etiologie ANKENT - experimentálního modelu pro lidskou ankylozující spondylitidu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Autoimmunity Reviews

ISSN

1568-9972

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

Suppl. 2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

1

Strana od-do

108

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—