Exprese genů pro cytochrom P450 v CD34(+) hematopoietických kmenových a progenitorových buňkách

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00027878" target="_blank" >RIV/68378050:_____/05:00027878 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/05:00006311 RIV/61989592:15110/05:00002051

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of cytochrome P450 genes in CD34(+) hematopoietic stem and progenitor cells

Popis výsledku v původním jazyce

The cytochrome P450s are an essential group of enzymes involved in metabolism of many substances including drugs and foreign chemicals. These enzymes inactivate toxic chemicals, including chemotherapeutic agents and also participate in drug bioactivation. These reactions primarily occur in organs and tissues known to express cytochrome P450 ubiquitously (i.e. liver and gastrointestinal tract). Cytochrome 450s are functional in other normal tissues as well as in tumours. The expression pattern of p450 isoforms in many tissues is not known. The published study elucidated the expression of P450s in purified hematopoietic CD34+ stem/progenitor cells. P450 1B1 and P450 2E1 isoforms were expressed while no sythesis of P450 3A4, P450 3A7, and P450 2C9 was observed. Both expressed isoforms are known to be connected with cancer cells and with activation of procarcinogens. Thus, early blood cells might be especially sensitive to several xenobiotics.

Název v anglickém jazyce

Expression of cytochrome P450 genes in CD34(+) hematopoietic stem and progenitor cells

Popis výsledku anglicky

The cytochrome P450s are an essential group of enzymes involved in metabolism of many substances including drugs and foreign chemicals. These enzymes inactivate toxic chemicals, including chemotherapeutic agents and also participate in drug bioactivation. These reactions primarily occur in organs and tissues known to express cytochrome P450 ubiquitously (i.e. liver and gastrointestinal tract). Cytochrome 450s are functional in other normal tissues as well as in tumours. The expression pattern of p450 isoforms in many tissues is not known. The published study elucidated the expression of P450s in purified hematopoietic CD34+ stem/progenitor cells. P450 1B1 and P450 2E1 isoforms were expressed while no sythesis of P450 3A4, P450 3A7, and P450 2C9 was observed. Both expressed isoforms are known to be connected with cancer cells and with activation of procarcinogens. Thus, early blood cells might be especially sensitive to several xenobiotics.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stem Cells

ISSN

1066-5099

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1417-1422

Kód UT WoS článku

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EID výsledku v databázi Scopus

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