Proteiny Myb indukují v buňkách neurální lišty melanocytární osud cestou aktivace receptoru c-kit

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00093160" target="_blank" >RIV/68378050:_____/07:00093160 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit

Popis výsledku v původním jazyce

The c-myb proto-oncogene and its oncogenic derivative v-mybAMV encode transcriptional regulators engaged in the commitment of hematopoietic cells. While the c-Myb protein is important for the formation and differentiation of various progenitors, the v-MybAMV oncoprotein induces in chicks a progression and transformation of the single (monoblastic) cell lineage. In this article the evidence is presented that c-Myb and v-MybAMV proteins have cell fate-directing abilities also in avian neural crest (NC), where both proteins determine the melanocytogenesis. Both Myb proteins activate in NC cells expression of the c-kit gene and the stem cell factor-c-Kit signaling ? one of the essential pathways in melanocyte development. These observations bring evidencethat the c-myb-c-kit pathway represents a common regulatory scheme for both hematopoietic and neural progenitors and establish a novel experimental model for studies of melanocytogenesis and melanocyte transformation.

Název v anglickém jazyce

The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit

Popis výsledku anglicky

The c-myb proto-oncogene and its oncogenic derivative v-mybAMV encode transcriptional regulators engaged in the commitment of hematopoietic cells. While the c-Myb protein is important for the formation and differentiation of various progenitors, the v-MybAMV oncoprotein induces in chicks a progression and transformation of the single (monoblastic) cell lineage. In this article the evidence is presented that c-Myb and v-MybAMV proteins have cell fate-directing abilities also in avian neural crest (NC), where both proteins determine the melanocytogenesis. Both Myb proteins activate in NC cells expression of the c-kit gene and the stem cell factor-c-Kit signaling ? one of the essential pathways in melanocyte development. These observations bring evidencethat the c-myb-c-kit pathway represents a common regulatory scheme for both hematopoietic and neural progenitors and establish a novel experimental model for studies of melanocytogenesis and melanocyte transformation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cellular and Molecular Life Sciences

ISSN

1420-682X

e-ISSN

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Svazek periodika

64

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

2975-2984

Kód UT WoS článku

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EID výsledku v databázi Scopus

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