Rozdíly v patogenitě mezi kmeny ptačích leukosních virů o stejné nebo rozdílné podskupinové specificitě

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00094254" target="_blank" >RIV/68378050:_____/07:00094254 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/07:00000392

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Differences in pathogenicity among strains of the same or different avian leukosis virus subgroups

Popis výsledku v původním jazyce

The most conspicuous symptoms of the wasting disease (WD) in chickens were induced by ALV subgroup C inoculated in mid embryogenesis. Almost comparable pathogenicity was exhibited by ALV subgroup D, viruses of subgroup B and A proved to be moderately andalmost non-pathogenic, respectively. The minimal virus dose efficiently inducing WD was > 102 infectious units of ALV subgroup C. WD was accompanied by depletion of lymphocytes in the thymus, bursa and spleen. The number of dendritic cells in the thymusand spleen was decreased while in the bursa was increased. An increased number of macrophages in the thymus and spleen corresponded with the observed general activation of the monocyte-macrophage system. In the spleen, CD4+T cells were reduced while CD8+ T cells were increased. Diseased animals failed to respond to Brucella antigen and their splenocytes failed to respond to Concanavalin A, both of which pointed to the damage of immune reactivity.

Název v anglickém jazyce

Differences in pathogenicity among strains of the same or different avian leukosis virus subgroups

Popis výsledku anglicky

The most conspicuous symptoms of the wasting disease (WD) in chickens were induced by ALV subgroup C inoculated in mid embryogenesis. Almost comparable pathogenicity was exhibited by ALV subgroup D, viruses of subgroup B and A proved to be moderately andalmost non-pathogenic, respectively. The minimal virus dose efficiently inducing WD was > 102 infectious units of ALV subgroup C. WD was accompanied by depletion of lymphocytes in the thymus, bursa and spleen. The number of dendritic cells in the thymusand spleen was decreased while in the bursa was increased. An increased number of macrophages in the thymus and spleen corresponded with the observed general activation of the monocyte-macrophage system. In the spleen, CD4+T cells were reduced while CD8+ T cells were increased. Diseased animals failed to respond to Brucella antigen and their splenocytes failed to respond to Concanavalin A, both of which pointed to the damage of immune reactivity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA523%2F04%2F0489" target="_blank" >GA523/04/0489: Patogenní působení ptačích leukózových virů (ALV): molekulární a genetické aspekty</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Avian Pathology

ISSN

0307-9457

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

15-27

Kód UT WoS článku

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EID výsledku v databázi Scopus

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