Krystaliny čtyřhranek: důkaz konvergentní evoluce Pax regulačních sekvencí

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F08%3A00310878" target="_blank" >RIV/68378050:_____/08:00310878 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cubozoan crystallins: evidence for convergent evolution of Pax regulatory sequences

Popis výsledku v původním jazyce

Cnidaria is the earliest-branching metazoan phylum containing a well-developed lens-containing visual system located on specialized sensory structures, rhopalia. Each rhopalium in cubozoan jellyfish T. cystophora has a large and a small complex, camera-type eye with a cellular lens containing distinct families of crystallins. Here we characterized J2-crystallin and its gene in T. cystophora. Although nonfunctional in transfected mammalian lens cells, J2-crystallin promoter is activated by jellyfish paired domain transcription factor PaxB in cotransfection tests via binding to 3 paired domain sites. PaxB paired domain-binding sites were also identified in PaxB-regulated promoters of the J1A- and J1B-crystallin genes, which are not homologous to J2-crystallin gene. Crystallin recruitment of multifunctional proteins was thus driven by convergent changes involving Pax (and other transcription factors) in promoters of nonhomologous genes within and between species and within gene families.

Název v anglickém jazyce

Cubozoan crystallins: evidence for convergent evolution of Pax regulatory sequences

Popis výsledku anglicky

Cnidaria is the earliest-branching metazoan phylum containing a well-developed lens-containing visual system located on specialized sensory structures, rhopalia. Each rhopalium in cubozoan jellyfish T. cystophora has a large and a small complex, camera-type eye with a cellular lens containing distinct families of crystallins. Here we characterized J2-crystallin and its gene in T. cystophora. Although nonfunctional in transfected mammalian lens cells, J2-crystallin promoter is activated by jellyfish paired domain transcription factor PaxB in cotransfection tests via binding to 3 paired domain sites. PaxB paired domain-binding sites were also identified in PaxB-regulated promoters of the J1A- and J1B-crystallin genes, which are not homologous to J2-crystallin gene. Crystallin recruitment of multifunctional proteins was thus driven by convergent changes involving Pax (and other transcription factors) in promoters of nonhomologous genes within and between species and within gene families.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/1M0520" target="_blank" >1M0520: Centrum aplikované genomiky</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Evolution & Development

ISSN

1520-541X

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000252120200007

EID výsledku v databázi Scopus

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