MMP19 je nezbytná pro vývoj T buněk a pro imunitní odpoveď kůže zprostředkovanou T buňkami

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F08%3A00311095" target="_blank" >RIV/68378050:_____/08:00311095 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses

Popis výsledku v původním jazyce

MMP19 affects cell proliferation, adhesion and migration but its physiological role is unclear. To determine the role of MMP19 in vivo we generated MMP19-deficient mice. In a contact hypersensitivity model these mice showed impaired T cell-mediated immune reaction characterized by limited influx of inflammatory cells, low proliferation of keratinocytes and reduced number of activated CD8+ T cells in draining lymph nodes. In the inflamed tissue the low number of CD8+ T cells in MMP19-deficient mice correlated with low amounts of proinflammatory cytokines (lymphotactin, I-TAC). T cell populations in the blood of immature, unsensitized mice were diminished due to an altered maturation of thymocytes. In the thymus thymocytes exhibited low proliferation rates and the number of CD4+CD8+ double-positive cells was strongly augmented. Based on the phenotype of MMP19-deficient mice we propose that MMP19 is an important factor in cutaneous immune responses and influences T cell development.

Název v anglickém jazyce

MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses

Popis výsledku anglicky

MMP19 affects cell proliferation, adhesion and migration but its physiological role is unclear. To determine the role of MMP19 in vivo we generated MMP19-deficient mice. In a contact hypersensitivity model these mice showed impaired T cell-mediated immune reaction characterized by limited influx of inflammatory cells, low proliferation of keratinocytes and reduced number of activated CD8+ T cells in draining lymph nodes. In the inflamed tissue the low number of CD8+ T cells in MMP19-deficient mice correlated with low amounts of proinflammatory cytokines (lymphotactin, I-TAC). T cell populations in the blood of immature, unsensitized mice were diminished due to an altered maturation of thymocytes. In the thymus thymocytes exhibited low proliferation rates and the number of CD4+CD8+ double-positive cells was strongly augmented. Based on the phenotype of MMP19-deficient mice we propose that MMP19 is an important factor in cutaneous immune responses and influences T cell development.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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