Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Popis výsledku v původním jazyce

There are numerous concerns over the potential transfer of pathogens between species during clinical xenotransplantation. Porcine xenografts have been previously used to treat patients with severe burns. As pigs are a known source of zoonotic agents, many diseases must be excluded from pigs used for xenotransplantation. Clostridium difficile is a major cause of neonatal enteritis in pigs, with an important feature that pigs can be its asymptomatic carriers. We examined the incidence of C. difficile PCRribotypes present in healthy donor pigs to determine if pig faeces, and in particular contamination of skin with faeces, is a potential route for the transfer of C. difficile. Animals were found to have human ribotype 017 present in the faecal matter, but no C. difficile was isolated from skin samples taken from the same animals. Also, due to the risk factors associated with C. difficile infection, the antimicrobial susceptibility of the C. difficile isolates has been determined.

Název v anglickém jazyce

Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Popis výsledku anglicky

There are numerous concerns over the potential transfer of pathogens between species during clinical xenotransplantation. Porcine xenografts have been previously used to treat patients with severe burns. As pigs are a known source of zoonotic agents, many diseases must be excluded from pigs used for xenotransplantation. Clostridium difficile is a major cause of neonatal enteritis in pigs, with an important feature that pigs can be its asymptomatic carriers. We examined the incidence of C. difficile PCRribotypes present in healthy donor pigs to determine if pig faeces, and in particular contamination of skin with faeces, is a potential route for the transfer of C. difficile. Animals were found to have human ribotype 017 present in the faecal matter, but no C. difficile was isolated from skin samples taken from the same animals. Also, due to the risk factors associated with C. difficile infection, the antimicrobial susceptibility of the C. difficile isolates has been determined.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Xenotransplantation

ISSN

0908-665X

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

SG - Singapurská republika

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000273007400003

EID výsledku v databázi Scopus

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