LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES

Popis výsledku v původním jazyce

The laboratory mouse is the most common mammalian model organism for research of the human body functions and disorders. For experimental purposes mice selected from inbred strains, developed by many generations of brother-sister crosses, are usually used. Individual mice of a given inbred strain are therefore considered genetically identical. However, our preliminary observations suggest that for a number of phenotypic traits mice originating from the same litter are significantly more similar than mice coming from different litters of the same inbred strain. We estimated the size of this litter effect for a number of traits in several phenotypic studies. By means of simulation we showed that ignoring the litter effect may result in several fold higher false positive rate and severe underestimation of minimal sample size.

Název v anglickém jazyce

LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES

Popis výsledku anglicky

The laboratory mouse is the most common mammalian model organism for research of the human body functions and disorders. For experimental purposes mice selected from inbred strains, developed by many generations of brother-sister crosses, are usually used. Individual mice of a given inbred strain are therefore considered genetically identical. However, our preliminary observations suggest that for a number of phenotypic traits mice originating from the same litter are significantly more similar than mice coming from different litters of the same inbred strain. We estimated the size of this litter effect for a number of traits in several phenotypic studies. By means of simulation we showed that ignoring the litter effect may result in several fold higher false positive rate and severe underestimation of minimal sample size.

Druh

D - Stať ve sborníku

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

BIOINFORMATICS 2011, Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms

ISBN

978-989-8425-36-2

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

238-243

Název nakladatele

SCITEPRESS, AV D MANUELL, 27A 2 ESQ, SETUBAL, 2910-595, PORTUGAL

Místo vydání

SETUBAL, PORTUGAL

Místo konání akce

Setubal

Datum konání akce

26. 1. 2011

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000308455800038