Chromosome substitution strains: gene discovery, functional analysis, and systems studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00383217" target="_blank" >RIV/68378050:_____/12:00383217 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00335-012-9426-y" target="_blank" >http://dx.doi.org/10.1007/s00335-012-9426-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00335-012-9426-y" target="_blank" >10.1007/s00335-012-9426-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromosome substitution strains: gene discovery, functional analysis, and systems studies

Popis výsledku v původním jazyce

Laboratory mice are valuable in biomedical research in part because of the extraordinary diversity of genetic resources that are available for studies of complex genetic traits and as models for human biology and disease. Chromosome substitution strains(CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations, and systems analysis. CSSs are made by replacing a single chromosome in a host strain withthe corresponding chromosome from a donor strain. A complete CSS panel involves a total of 22 engineered inbred strains, one for each of the 19 autosomes, one each for the X and Y chromosomes, and one for mitochondria. A genome survey simply involves comparing each phenotype for each of the CSSs with the phenotypes of the host strain. The CSS panels that are available for laboratory mice have been used to dissect a remarkable variety of phenotypes and to characterize an impressive array

Název v anglickém jazyce

Chromosome substitution strains: gene discovery, functional analysis, and systems studies

Popis výsledku anglicky

Laboratory mice are valuable in biomedical research in part because of the extraordinary diversity of genetic resources that are available for studies of complex genetic traits and as models for human biology and disease. Chromosome substitution strains(CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations, and systems analysis. CSSs are made by replacing a single chromosome in a host strain withthe corresponding chromosome from a donor strain. A complete CSS panel involves a total of 22 engineered inbred strains, one for each of the 19 autosomes, one each for the X and Y chromosomes, and one for mitochondria. A genome survey simply involves comparing each phenotype for each of the CSSs with the phenotypes of the host strain. The CSS panels that are available for laboratory mice have been used to dissect a remarkable variety of phenotypes and to characterize an impressive array

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mammalian Genome

ISSN

0938-8990

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

9-10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

693-705

Kód UT WoS článku

000309543200020

EID výsledku v databázi Scopus

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