Dissecting the genetic architecture of F-1 hybrid sterility in house mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00383223" target="_blank" >RIV/68378050:_____/12:00383223 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x" target="_blank" >http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x" target="_blank" >10.1111/j.1558-5646.2012.01684.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dissecting the genetic architecture of F-1 hybrid sterility in house mice

Popis výsledku v původním jazyce

Hybrid sterility as a postzygotic reproductive isolation mechanism has been studied for over 80 years, yet the first identifications of hybrid sterility genes in Drosophila and mouse are quite recent. To study the genetic architecture of F-1 hybrid sterility between young subspecies of house mouse Mus m. domesticus and M. m. musculus, we conducted QTL analysis of a backcross between inbred strains representing these two subspecies and probed the role of individual chromosomes in hybrid sterility using the intersubspecific chromosome substitution strains. We provide direct evidence that the asymmetry in male infertility between reciprocal crosses is conferred by the middle region of M. m. musculus Chr X, thus excluding other potential candidates such asY, imprinted genes, and mitochondrial DNA. QTL analysis identified strong hybrid sterility loci on Chr 17 and Chr X and predicted a set of interchangeable autosomal loci, a subset of which is sufficient to activate the Dobzhansky-Muller

Název v anglickém jazyce

Dissecting the genetic architecture of F-1 hybrid sterility in house mice

Popis výsledku anglicky

Hybrid sterility as a postzygotic reproductive isolation mechanism has been studied for over 80 years, yet the first identifications of hybrid sterility genes in Drosophila and mouse are quite recent. To study the genetic architecture of F-1 hybrid sterility between young subspecies of house mouse Mus m. domesticus and M. m. musculus, we conducted QTL analysis of a backcross between inbred strains representing these two subspecies and probed the role of individual chromosomes in hybrid sterility using the intersubspecific chromosome substitution strains. We provide direct evidence that the asymmetry in male infertility between reciprocal crosses is conferred by the middle region of M. m. musculus Chr X, thus excluding other potential candidates such asY, imprinted genes, and mitochondrial DNA. QTL analysis identified strong hybrid sterility loci on Chr 17 and Chr X and predicted a set of interchangeable autosomal loci, a subset of which is sufficient to activate the Dobzhansky-Muller

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/LD11079" target="_blank" >LD11079: Nové myší modely pro studium biomedicínských komplexních znaků a lidských chorob a pro systémovou genetiku</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Evolution

ISSN

0014-3820

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

3321-3335

Kód UT WoS článku

000310477600002

EID výsledku v databázi Scopus

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