The canonical RNA interference pathway in animals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00390170" target="_blank" >RIV/68378050:_____/12:00390170 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-642-22517-8_5" target="_blank" >http://dx.doi.org/10.1007/978-3-642-22517-8_5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-642-22517-8_5" target="_blank" >10.1007/978-3-642-22517-8_5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The canonical RNA interference pathway in animals

Popis výsledku v původním jazyce

The canonical RNA interference (RNAi) pathway is defined as a sequence-specific mRNA degradation mediated by short RNA molecules which are generated from long double-stranded RNA. Since its discovery in 1998, RNAi has become a popular tool for experimental silencing of gene expression. On the other hand, its natural role received less attention. Recent studies in animal systems, particularly the use of the next generation sequencing and analysis of animals defective in some aspect of small RNA biogenesis, revealed novel functions of RNAi and cross talks between RNAi and other pathways employing small RNAs. This chapter provides a comprehensive view of the natural canonical RNAi pathway in animals including its molecular mechanism and different biological roles.

Název v anglickém jazyce

The canonical RNA interference pathway in animals

Popis výsledku anglicky

The canonical RNA interference (RNAi) pathway is defined as a sequence-specific mRNA degradation mediated by short RNA molecules which are generated from long double-stranded RNA. Since its discovery in 1998, RNAi has become a popular tool for experimental silencing of gene expression. On the other hand, its natural role received less attention. Recent studies in animal systems, particularly the use of the next generation sequencing and analysis of animals defective in some aspect of small RNA biogenesis, revealed novel functions of RNAi and cross talks between RNAi and other pathways employing small RNAs. This chapter provides a comprehensive view of the natural canonical RNAi pathway in animals including its molecular mechanism and different biological roles.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Regulatory RNAs: Basics, Methods and Applications

ISBN

978-3-642-22516-1

Počet stran výsledku

39

Strana od-do

111-149

Počet stran knihy

552

Název nakladatele

Springer

Místo vydání

Berlin - Heidelberg

Kód UT WoS kapitoly

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