New insight into transcription of human endogenous retroviral elements

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00394696" target="_blank" >RIV/68378050:_____/13:00394696 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.nbt.2012.11.009" target="_blank" >http://dx.doi.org/10.1016/j.nbt.2012.11.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nbt.2012.11.009" target="_blank" >10.1016/j.nbt.2012.11.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

New insight into transcription of human endogenous retroviral elements

Popis výsledku v původním jazyce

It is generally assumed that human endogenous retroviral elements (HERVs) belong to the class of genomic repetitive nucleotide sequences often called junk DNA?. These elements were categorized to families, and members of some of these families (e.g. HERV-H, HERV-W and HERV-K) were shown to be transcribed. These transcriptions were associated with several severe diseases such as mental disorders, AIDS, autoimmune diseases and cancer. In this review we discuss several bioinformatics strategies for genome-wide scan of HERVs transcription using high-throughput RNA sequencing on several platforms. We show that many more HERVs than previously described are transcribed to various levels and we discuss possible implications of these transcriptions.

Název v anglickém jazyce

New insight into transcription of human endogenous retroviral elements

Popis výsledku anglicky

It is generally assumed that human endogenous retroviral elements (HERVs) belong to the class of genomic repetitive nucleotide sequences often called junk DNA?. These elements were categorized to families, and members of some of these families (e.g. HERV-H, HERV-W and HERV-K) were shown to be transcribed. These transcriptions were associated with several severe diseases such as mental disorders, AIDS, autoimmune diseases and cancer. In this review we discuss several bioinformatics strategies for genome-wide scan of HERVs transcription using high-throughput RNA sequencing on several platforms. We show that many more HERVs than previously described are transcribed to various levels and we discuss possible implications of these transcriptions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GCP305%2F10%2FJ052" target="_blank" >GCP305/10/J052: Funkční analýza endogenních retrovirových elementů v lidském genomu: hledání spojení s rakovinou</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

New Biotechnology

ISSN

1871-6784

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

314-318

Kód UT WoS článku

000317240000010

EID výsledku v databázi Scopus

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