Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423257" target="_blank" >RIV/68378050:_____/13:00423257 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11010-013-1752-1" target="_blank" >http://dx.doi.org/10.1007/s11010-013-1752-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-013-1752-1" target="_blank" >10.1007/s11010-013-1752-1</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins
Popis výsledku v původním jazyce
The TNF-related apoptosis inducing ligand (TRAIL) has promising anti-cancer therapeutic activity, although significant percentage of primary tumors resistant to TRAIL-induced apoptosis remains an obstacle to the extensive use of TRAIL-based mono-therapies. Natural compound curcumin could potentially sensitize resistant cancer cells to TRAIL. We found that the combination of TRAIL with curcumin can synergistically induces apoptosis in three TRAIL-resistant breast cancer cell lines. The mechanism behind this synergistic cell death was investigated by examining an effect of curcumin on the expression and activation of TRAIL-associated cell death proteins. Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealeddifferential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt. Curcumin-induced production of reactive oxygen species did not affect total expression of DR5 but it enhanced mobilization of DR5 to the plasma me
Název v anglickém jazyce
Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins
Popis výsledku anglicky
The TNF-related apoptosis inducing ligand (TRAIL) has promising anti-cancer therapeutic activity, although significant percentage of primary tumors resistant to TRAIL-induced apoptosis remains an obstacle to the extensive use of TRAIL-based mono-therapies. Natural compound curcumin could potentially sensitize resistant cancer cells to TRAIL. We found that the combination of TRAIL with curcumin can synergistically induces apoptosis in three TRAIL-resistant breast cancer cell lines. The mechanism behind this synergistic cell death was investigated by examining an effect of curcumin on the expression and activation of TRAIL-associated cell death proteins. Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealeddifferential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt. Curcumin-induced production of reactive oxygen species did not affect total expression of DR5 but it enhanced mobilization of DR5 to the plasma me
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
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Svazek periodika
383
Číslo periodika v rámci svazku
1-2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
39-48
Kód UT WoS článku
000325136400005
EID výsledku v databázi Scopus
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