Pax2/5/8 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455797" target="_blank" >RIV/68378050:_____/15:00455797 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.3389/fgene.2015.00228" target="_blank" >http://dx.doi.org/10.3389/fgene.2015.00228</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fgene.2015.00228" target="_blank" >10.3389/fgene.2015.00228</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Pax2/5/8 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain
Popis výsledku v původním jazyce
Paired box transcription factors play important role in development and tissue morphogenesis. The number of Pax homologs varies among species studied so far, due to genome and gene duplications that have affected PAX family to a great extent. Based on sequence similarity and functional domains, four Pax classes have been identified in chordates, namely Pax1/9, Pax2/5/8, Pax3/7, and Pax4/6. Numerous splicing events have been reported mainly for Pax2/5/8 and Pax6 genes. Of significant interest are those events that lead to Pax proteins with presumed novel properties, such as altered DNA-binding or transcriptional activity. In the current study, a thorough analysis of Pax2/5/8 splicing events from cephalochordates and vertebrates was performed. We focusedmore on Pax2/5/8 and Pax6 splicing events in which the paired domain is involved. Three new splicing events were identified in Oryzias Wipes, one of which seems to be conserved in Acanthomorphata. Using representatives from deuterostome
Název v anglickém jazyce
Pax2/5/8 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain
Popis výsledku anglicky
Paired box transcription factors play important role in development and tissue morphogenesis. The number of Pax homologs varies among species studied so far, due to genome and gene duplications that have affected PAX family to a great extent. Based on sequence similarity and functional domains, four Pax classes have been identified in chordates, namely Pax1/9, Pax2/5/8, Pax3/7, and Pax4/6. Numerous splicing events have been reported mainly for Pax2/5/8 and Pax6 genes. Of significant interest are those events that lead to Pax proteins with presumed novel properties, such as altered DNA-binding or transcriptional activity. In the current study, a thorough analysis of Pax2/5/8 splicing events from cephalochordates and vertebrates was performed. We focusedmore on Pax2/5/8 and Pax6 splicing events in which the paired domain is involved. Three new splicing events were identified in Oryzias Wipes, one of which seems to be conserved in Acanthomorphata. Using representatives from deuterostome
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in genetics
ISSN
1664-8021
e-ISSN
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Svazek periodika
6
Číslo periodika v rámci svazku
Jul 2
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
12
Strana od-do
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Kód UT WoS článku
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EID výsledku v databázi Scopus
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