Fibrillarin from Archaea to human

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455869" target="_blank" >RIV/68378050:_____/15:00455869 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/boc.201400077" target="_blank" >http://dx.doi.org/10.1111/boc.201400077</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/boc.201400077" target="_blank" >10.1111/boc.201400077</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fibrillarin from Archaea to human

Popis výsledku v původním jazyce

Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negativeregulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.

Název v anglickém jazyce

Fibrillarin from Archaea to human

Popis výsledku anglicky

Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negativeregulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biology of the Cell

ISSN

0248-4900

e-ISSN

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Svazek periodika

107

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

16

Strana od-do

159-174

Kód UT WoS článku

000355769100001

EID výsledku v databázi Scopus

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