A systematic computational analysis of the rRNA-3 ' UTR sequence complementarity suggests a regulatory mechanism influencing post-termination events in metazoan translation

Kód výsledku v IS VaVaI

RIV/68378050:_____/16:00463032 - isvavai.cz

Nalezeny alternativní kódy

RIV/61388971:_____/16:00463032

Výsledek na webu

http://dx.doi.org/10.1261/rna.056119.116

DOI - Digital Object Identifier

10.1261/rna.056119.116

Jazyk výsledku

angličtina

Název v původním jazyce

A systematic computational analysis of the rRNA-3 ' UTR sequence complementarity suggests a regulatory mechanism influencing post-termination events in metazoan translation

Popis výsledku v původním jazyce

Nucleic acid sequence complementarity underlies many fundamental biological processes. Although first noticed a long time ago, sequence complementarity between mRNAs and ribosomal RNAs still lacks a meaningful biological interpretation. Here we used statistical analysis of large-scale sequence data sets and high-throughput computing to explore complementarity between 18S and 28S rRNAs and mRNA 3' UTR sequences. By the analysis of 27,646 full-length 3' UTR sequences from 14 species covering both protozoans and metazoans, we show that the computed 18S rRNA complementarity creates an evolutionarily conserved localization pattern centered around the ribosomal mRNA entry channel, suggesting its biological relevance and functionality.

Název v anglickém jazyce

A systematic computational analysis of the rRNA-3 ' UTR sequence complementarity suggests a regulatory mechanism influencing post-termination events in metazoan translation

Popis výsledku anglicky

Nucleic acid sequence complementarity underlies many fundamental biological processes. Although first noticed a long time ago, sequence complementarity between mRNAs and ribosomal RNAs still lacks a meaningful biological interpretation. Here we used statistical analysis of large-scale sequence data sets and high-throughput computing to explore complementarity between 18S and 28S rRNAs and mRNA 3' UTR sequences. By the analysis of 27,646 full-length 3' UTR sequences from 14 species covering both protozoans and metazoans, we show that the computed 18S rRNA complementarity creates an evolutionarily conserved localization pattern centered around the ribosomal mRNA entry channel, suggesting its biological relevance and functionality.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

—

Projekt

GBP305/12/G034: Centrum biologie RNA

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

R N A

ISSN

1355-8382

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

957-967-957-967

Kód UT WoS článku

000378068900002

EID výsledku v databázi Scopus

2-s2.0-84975041736