Expression of FGFs during early mouse tongue development
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00472120" target="_blank" >RIV/68378050:_____/16:00472120 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.gep.2015.12.003" target="_blank" >http://dx.doi.org/10.1016/j.gep.2015.12.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.gep.2015.12.003" target="_blank" >10.1016/j.gep.2015.12.003</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Expression of FGFs during early mouse tongue development
Popis výsledku v původním jazyce
The fibroblast growth factors (FGFs) constitute one of the largest growth factor families, and several ligands and receptors in this family are known to play critical roles during tongue development. In order to provide a comprehensive foundation for research into the role of FGFs during the process of tongue formation, we measured the transcript levels by quantitative PCR and mapped the expression patterns by in situ hybridization of all 22 Fgfs during mouse tongue development between embryonic days (E) 11.5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme. Our results indicate that FGF signaling regulates tongue development at multiple stages. (C) 2016 Elsevier B.V. All rights reserved.
Název v anglickém jazyce
Expression of FGFs during early mouse tongue development
Popis výsledku anglicky
The fibroblast growth factors (FGFs) constitute one of the largest growth factor families, and several ligands and receptors in this family are known to play critical roles during tongue development. In order to provide a comprehensive foundation for research into the role of FGFs during the process of tongue formation, we measured the transcript levels by quantitative PCR and mapped the expression patterns by in situ hybridization of all 22 Fgfs during mouse tongue development between embryonic days (E) 11.5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme. Our results indicate that FGF signaling regulates tongue development at multiple stages. (C) 2016 Elsevier B.V. All rights reserved.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Gene Expression Patterns
ISSN
1567-133X
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
81-87
Kód UT WoS článku
000375160800001
EID výsledku v databázi Scopus
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