X-ray-based microstructural analysis of hydrogel-based composites for bone tissue engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00480347" target="_blank" >RIV/68378050:_____/17:00480347 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378297:_____/17:00480347

Výsledek na webu

<a href="http://icmt25.com/e_files/content/Preliminary_BookOfAbstracts_25ICM&T.pdf" target="_blank" >http://icmt25.com/e_files/content/Preliminary_BookOfAbstracts_25ICM&T.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

X-ray-based microstructural analysis of hydrogel-based composites for bone tissue engineering

Popis výsledku v původním jazyce

Artificial bone structures implantation becomes a promising treatment procedure in regenerative medicine. To ensure proper function of the scaffold its structural, mechanical and permeability properties have to be investigated and optimized. This study is focused on biodegradable hydrogel gellan gum (GG) reinforced by bioactive glass (BAG) nanoparticles with 0, 50 and 70 wt.%. The samples were subjected to tomografic imaging to obtain detail information about the internal microstructure and BAG particles distribution. As a comparative measurement planar energydispersive X-ray spectroscopy using scanning electron microscope and nanoindentation measurement were performed. The microtomography inspection was performed using the patented (European patent no. EP2835631) in-house designed modular radiographic imaging device equipped with scintillators, large single photon counting and spectroscopic detectors. From reconstructed volumetric data internal microarchitecture, porosity, cell-wall thickness and BAG distribution were derived. The results were compared with the results of the planar analysis of thin scaffold layers prepared by cryosection.

Název v anglickém jazyce

X-ray-based microstructural analysis of hydrogel-based composites for bone tissue engineering

Popis výsledku anglicky

Artificial bone structures implantation becomes a promising treatment procedure in regenerative medicine. To ensure proper function of the scaffold its structural, mechanical and permeability properties have to be investigated and optimized. This study is focused on biodegradable hydrogel gellan gum (GG) reinforced by bioactive glass (BAG) nanoparticles with 0, 50 and 70 wt.%. The samples were subjected to tomografic imaging to obtain detail information about the internal microstructure and BAG particles distribution. As a comparative measurement planar energydispersive X-ray spectroscopy using scanning electron microscope and nanoindentation measurement were performed. The microtomography inspection was performed using the patented (European patent no. EP2835631) in-house designed modular radiographic imaging device equipped with scintillators, large single photon counting and spectroscopic detectors. From reconstructed volumetric data internal microarchitecture, porosity, cell-wall thickness and BAG distribution were derived. The results were compared with the results of the planar analysis of thin scaffold layers prepared by cryosection.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů