Small molecule modulators of Wnt/β-catenin-driven gene expression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00502878" target="_blank" >RIV/68378050:_____/19:00502878 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Small molecule modulators of Wnt/β-catenin-driven gene expression

Popis výsledku v původním jazyce

The Wnt pathway represents an evolutionarily conserved signaling mechanism that governs transcriptional programs responsible for proper embryonic development and homeostasis of multiple adult organs. In healthy tissues, canonical -catenin-dependent Wnt signaling is indispensable for stem cell maintenance. In contrast, aberrant Wnt pathway activation underlies a number of diseases, most notably various types of solid cancers and leukemia. The Wnt signal-transducing cascade includes multiple components involved in the pathway regulation. In the past 20 years, great effort has been concentrated on discovering and characterizing these components. Additionally, many small molecule compounds that influence the Wnt signaling output have been identified. Wnt signaling inhibitors might be used for improved cancer therapy. On the other hand, as culture media constituents, the Wnt activators can support growth of adult stem cells in vitro. Both of these usages make search for modulators of Wnt signaling an attractive area of biomedical research. In this review, we summarize a number of compounds that were recently shown to effectively modulate Wnt/β-catenin signaling. As our team has identified some of these compounds, the review also focuses on experimental tools and methods used to identify and test small molecule inhibitors of Wnt signaling.

Název v anglickém jazyce

Small molecule modulators of Wnt/β-catenin-driven gene expression

Popis výsledku anglicky

The Wnt pathway represents an evolutionarily conserved signaling mechanism that governs transcriptional programs responsible for proper embryonic development and homeostasis of multiple adult organs. In healthy tissues, canonical -catenin-dependent Wnt signaling is indispensable for stem cell maintenance. In contrast, aberrant Wnt pathway activation underlies a number of diseases, most notably various types of solid cancers and leukemia. The Wnt signal-transducing cascade includes multiple components involved in the pathway regulation. In the past 20 years, great effort has been concentrated on discovering and characterizing these components. Additionally, many small molecule compounds that influence the Wnt signaling output have been identified. Wnt signaling inhibitors might be used for improved cancer therapy. On the other hand, as culture media constituents, the Wnt activators can support growth of adult stem cells in vitro. Both of these usages make search for modulators of Wnt signaling an attractive area of biomedical research. In this review, we summarize a number of compounds that were recently shown to effectively modulate Wnt/β-catenin signaling. As our team has identified some of these compounds, the review also focuses on experimental tools and methods used to identify and test small molecule inhibitors of Wnt signaling.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Chemical Biology

ISBN

978-80-88011-03-3

Počet stran výsledku

15

Strana od-do

2-19

Počet stran knihy

210

Název nakladatele

OPTIO CZ

Místo vydání

Praha

Kód UT WoS kapitoly

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