Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00505232" target="_blank" >RIV/68378050:_____/19:00505232 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.hh.um.es/Abstracts/Vol_34/34_1/34_1_81.htm" target="_blank" >https://www.hh.um.es/Abstracts/Vol_34/34_1/34_1_81.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14670/HH-18-027" target="_blank" >10.14670/HH-18-027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival

Popis výsledku v původním jazyce

Introduction. It has been reported that overexpression and altered compartmentalization of gamma-tubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of human malignancies. We have shown that gamma-tubulin expression and cellular distribution pattern is also altered in non-small cell lung cancer (NSCLC) (Histol. Histopathol. 2012, 27: 11831194). In the present study we examined the relationship between gamma-tubulin expression and patient overall survival (OS). Material and methods. Immunohistochemistry was performed, with well-characterized anti-gamma-tubulin antibodies, on 109 formalin-fixed, paraffin-embedded NSCLC specimens (p-TNM stage I-III). gamma-Tubulin labeling indexes (LIs) were determined, and the association of gamma-tubulin expression with clinicopathological parameters was evaluated. To analyze OS rates according to gamma-tubulin LIs, patients were categorized into three groups: those with low (0-30%), intermediate (31-69%) or high (70-100%) gamma-tubulin LI. Association of clinicopathological parameters and gamma-tubulin with survival were examined using univariate and multivariate Cox regression analysis. Results. No statistically significant association was seen between gamma-tubulin overexpression and histological type, tumor differentiation, p-TNM stage and adenocarcinoma subtyping. Longer survival was observed in the high gamma-tubulin LI group of patients with p-TNM stages II+III when compared to intermediate or low gamma-tubulin LI groups, but the difference was not statistically significant (p=0.066). On the other hand, when combined low and intermediate gamma-tubulin LI groups (p-TNM stages II+III) where compared to high gamma-tubulin LI group, statistically significant longer survival was observed in high gamma-tubulin group (p=0.021). Conclusion. Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced NSCLC stages.

Název v anglickém jazyce

Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival

Popis výsledku anglicky

Introduction. It has been reported that overexpression and altered compartmentalization of gamma-tubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of human malignancies. We have shown that gamma-tubulin expression and cellular distribution pattern is also altered in non-small cell lung cancer (NSCLC) (Histol. Histopathol. 2012, 27: 11831194). In the present study we examined the relationship between gamma-tubulin expression and patient overall survival (OS). Material and methods. Immunohistochemistry was performed, with well-characterized anti-gamma-tubulin antibodies, on 109 formalin-fixed, paraffin-embedded NSCLC specimens (p-TNM stage I-III). gamma-Tubulin labeling indexes (LIs) were determined, and the association of gamma-tubulin expression with clinicopathological parameters was evaluated. To analyze OS rates according to gamma-tubulin LIs, patients were categorized into three groups: those with low (0-30%), intermediate (31-69%) or high (70-100%) gamma-tubulin LI. Association of clinicopathological parameters and gamma-tubulin with survival were examined using univariate and multivariate Cox regression analysis. Results. No statistically significant association was seen between gamma-tubulin overexpression and histological type, tumor differentiation, p-TNM stage and adenocarcinoma subtyping. Longer survival was observed in the high gamma-tubulin LI group of patients with p-TNM stages II+III when compared to intermediate or low gamma-tubulin LI groups, but the difference was not statistically significant (p=0.066). On the other hand, when combined low and intermediate gamma-tubulin LI groups (p-TNM stages II+III) where compared to high gamma-tubulin LI group, statistically significant longer survival was observed in high gamma-tubulin group (p=0.021). Conclusion. Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced NSCLC stages.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Histology and Histopathology

ISSN

0213-3911

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

10

Strana od-do

81-90

Kód UT WoS článku

000452158000008

EID výsledku v databázi Scopus

—