Gene Expression in Patients With Abdominal Aortic Aneurysm More Than Immunological Mechanisms Involved

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00522800" target="_blank" >RIV/68378050:_____/19:00522800 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/19:00008170

Výsledek na webu

<a href="https://doi.org/10.33549/physiolres.933905" target="_blank" >https://doi.org/10.33549/physiolres.933905</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.933905" target="_blank" >10.33549/physiolres.933905</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gene Expression in Patients With Abdominal Aortic Aneurysm More Than Immunological Mechanisms Involved

Popis výsledku v původním jazyce

Abdominal aortic aneurysm (AAA) is a serious condition of unclear pathogenesis and progression. Two samples were collected from 48 patients during AAA surgery. One sample was collected from the aneurysm, the other from the aneurysm proximal neck where the tissue did not exhibit any aneurysmal changes. Subsequently, gene expression profiles using microarrays (Illumina) were compared in RNA extracted from the samples. Overall, 2,185 genes were found to be upregulated and 2,100 downregulated, from which 158 genes had a different expression with FDR<0.05 (False Discovery Rate) and FC >= 2 (Fold Change). Of this number, 115 genes were over-expressed and 43 under-expressed. The analysis of the gene list based on their biological pathways revealed that the regulation of inflammation was mediated by chemokine and cytokine signaling pathways, the integrin signaling pathway, and T and B cell activation. Moreover, a change was identified in the expression of genes involved in both intercellular and intracellular signaling systems.

Název v anglickém jazyce

Gene Expression in Patients With Abdominal Aortic Aneurysm More Than Immunological Mechanisms Involved

Popis výsledku anglicky

Abdominal aortic aneurysm (AAA) is a serious condition of unclear pathogenesis and progression. Two samples were collected from 48 patients during AAA surgery. One sample was collected from the aneurysm, the other from the aneurysm proximal neck where the tissue did not exhibit any aneurysmal changes. Subsequently, gene expression profiles using microarrays (Illumina) were compared in RNA extracted from the samples. Overall, 2,185 genes were found to be upregulated and 2,100 downregulated, from which 158 genes had a different expression with FDR<0.05 (False Discovery Rate) and FC >= 2 (Fold Change). Of this number, 115 genes were over-expressed and 43 under-expressed. The analysis of the gene list based on their biological pathways revealed that the regulation of inflammation was mediated by chemokine and cytokine signaling pathways, the integrin signaling pathway, and T and B cell activation. Moreover, a change was identified in the expression of genes involved in both intercellular and intracellular signaling systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

—

Svazek periodika

68

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

385-394

Kód UT WoS článku

000476830200005

EID výsledku v databázi Scopus

—