Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00522841" target="_blank" >RIV/68378050:_____/19:00522841 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00336C#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00336C#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c9pp00336c" target="_blank" >10.1039/c9pp00336c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy

Popis výsledku v původním jazyce

We report the first exocyclically metallated tetrapyridinoporphyrazine, [tetrakis-(trans-Pt(NH3)(2)Cl)-tetra(3,4-pyrido)porphyrazine-zinc(ii)](NO3)(4) (4), synthesized in a multistep synthesis starting from 3,4-pyridinedicarbonitrile (1). The synthetic procedure involved a platination reaction of the intermediate tetra(3,4-pyrido)porphyrazine-zinc(ii) (2), whereby the zinc(ii) enhanced the solubility of the intermediate enabling the platination reaction. A similar approach to synthesize [tetrakis-(trans-Pt(NH3)(2)Cl)-tetra(3,4-pyrido)porphyrazine](NO3)(4) (5) failed due to the unsuitable solubility properties of the intermediate tetra(3,4-pyrido)porphyrazine (3). The final product 4 and the intermediates were characterized, the photochemical and photophysical properties were determined and the photocytotoxicities were investigated. We demonstrate that the platinated tetra-pyridinoporphyrazine 4 is a potential photosensitizer for photodynamic therapy (PDT).

Název v anglickém jazyce

Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy

Popis výsledku anglicky

We report the first exocyclically metallated tetrapyridinoporphyrazine, [tetrakis-(trans-Pt(NH3)(2)Cl)-tetra(3,4-pyrido)porphyrazine-zinc(ii)](NO3)(4) (4), synthesized in a multistep synthesis starting from 3,4-pyridinedicarbonitrile (1). The synthetic procedure involved a platination reaction of the intermediate tetra(3,4-pyrido)porphyrazine-zinc(ii) (2), whereby the zinc(ii) enhanced the solubility of the intermediate enabling the platination reaction. A similar approach to synthesize [tetrakis-(trans-Pt(NH3)(2)Cl)-tetra(3,4-pyrido)porphyrazine](NO3)(4) (5) failed due to the unsuitable solubility properties of the intermediate tetra(3,4-pyrido)porphyrazine (3). The final product 4 and the intermediates were characterized, the photochemical and photophysical properties were determined and the photocytotoxicities were investigated. We demonstrate that the platinated tetra-pyridinoporphyrazine 4 is a potential photosensitizer for photodynamic therapy (PDT).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GA17-02080S" target="_blank" >GA17-02080S: Studium molekulárních mechanismů podílejících se na potlačení genetické nestability spojené s transkripcí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Photochemical & Photobiological Sciences

ISSN

1474-905X

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

2792-2803

Kód UT WoS článku

000494732600017

EID výsledku v databázi Scopus

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