Human stem cell derived disease models for retinitis pigmentosa. Advances in Disease Models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523210" target="_blank" >RIV/68378050:_____/19:00523210 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Human stem cell derived disease models for retinitis pigmentosa. Advances in Disease Models

Popis výsledku v původním jazyce

Given complexity and health impact of retinitis pigmentosa a better understanding of its pathogenesis is of major importance. Often used research models, such as mouse models, have been shown to insufficiently recapitulate the retinitis pigmentosa phenotype as it is observed in human patients. With the invention of induced pluripotent stem cells and the advances in retinal differentiation in the last decade new possibilities for retinal disease modeling have emerged. Two-dimensional and even three-dimensional in vitro models, known as retinal organoids, have been successfully derived from human stem cells. In this manuscript we describe and discuss the development of these stem cell derived retina models and their applications in retinitis pigmentosa research.

Název v anglickém jazyce

Human stem cell derived disease models for retinitis pigmentosa. Advances in Disease Models

Popis výsledku anglicky

Given complexity and health impact of retinitis pigmentosa a better understanding of its pathogenesis is of major importance. Often used research models, such as mouse models, have been shown to insufficiently recapitulate the retinitis pigmentosa phenotype as it is observed in human patients. With the invention of induced pluripotent stem cells and the advances in retinal differentiation in the last decade new possibilities for retinal disease modeling have emerged. Two-dimensional and even three-dimensional in vitro models, known as retinal organoids, have been successfully derived from human stem cells. In this manuscript we describe and discuss the development of these stem cell derived retina models and their applications in retinitis pigmentosa research.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1419" target="_blank" >LO1419: Biomodely pro zdraví - Centrum modelových organismů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Disease Models

ISBN

978-80-88011-06-4

Počet stran výsledku

10

Strana od-do

1-310

Počet stran knihy

310

Název nakladatele

OPTIO CZ

Místo vydání

Praha

Kód UT WoS kapitoly

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